Results 1  10
of
290,538
Haploview: analysis and visualization of LD and haplotype maps
 BIOINFORMATICS
, 2005
"... Summary: Research over the last few years has revealed significant haplotype structure in the human genome. The characterization of these patterns, particularly in the context of medical genetic association studies, is becoming a routine research activity. Haploview is a software package that prov ..."
Abstract

Cited by 1213 (5 self)
 Add to MetaCart
age that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface.
Multipoint quantitativetrait linkage analysis in general pedigrees
 Am. J. Hum. Genet
, 1998
"... Multipoint linkage analysis of quantitativetrait loci (QTLs) has previously been restricted to sibships and small pedigrees. In this article, we show how variancecomponent linkage methods can be used in pedigrees of arbitrary size and complexity, and we develop a general framework for multipoint i ..."
Abstract

Cited by 549 (56 self)
 Add to MetaCart
Multipoint linkage analysis of quantitativetrait loci (QTLs) has previously been restricted to sibships and small pedigrees. In this article, we show how variancecomponent linkage methods can be used in pedigrees of arbitrary size and complexity, and we develop a general framework for multipoint
The moderatorâ€“mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations
 Journal of Personality and Social Psychology
, 1986
"... In this article, we attempt to distinguish between the properties of moderator and mediator variables at a number of levels. First, we seek to make theorists and researchers aware of the importance of not using the terms moderator and mediator interchangeably by carefully elaborating, both conceptua ..."
Abstract

Cited by 5261 (7 self)
 Add to MetaCart
In this article, we attempt to distinguish between the properties of moderator and mediator variables at a number of levels. First, we seek to make theorists and researchers aware of the importance of not using the terms moderator and mediator interchangeably by carefully elaborating, both conceptually and strategically, the many ways in which moderators and mediators differ. We then go beyond this largely pedagogical function and delineate the conceptual and strategic implications of making use of such distinctions with regard to a wide range of phenomena, including control and stress, attitudes, and personality traits. We also provide a specific compendium of analytic procedures appropriate for making the most effective use of the moderator and mediator distinction, both separately and in terms of a broader causal system that includes both moderators and mediators. The purpose of this analysis is to distinguish between the properties of moderator and mediator variables in such a way as to clarify the different ways in which conceptual variables may account for differences in peoples ' behavior. Specifically, we differentiate between two oftenconfused functions of third variables: (a) the moderator function of third variables, which
Estimating the number of clusters in a dataset via the Gap statistic
, 2000
"... We propose a method (the \Gap statistic") for estimating the number of clusters (groups) in a set of data. The technique uses the output of any clustering algorithm (e.g. kmeans or hierarchical), comparing the change in within cluster dispersion to that expected under an appropriate reference ..."
Abstract

Cited by 492 (1 self)
 Add to MetaCart
We propose a method (the \Gap statistic") for estimating the number of clusters (groups) in a set of data. The technique uses the output of any clustering algorithm (e.g. kmeans or hierarchical), comparing the change in within cluster dispersion to that expected under an appropriate reference
Sketchpad: A manmachine graphical communication system
, 2003
"... The Sketchpad system uses drawing as a novel communication medium for a computer. The system contains input, output, and computation programs which enable it to interpret information drawn directly on a computer display. It has been used to draw electrical, mechanical, scientific, mathematical, and ..."
Abstract

Cited by 702 (6 self)
 Add to MetaCart
, and animated drawings; it is a general purpose system. Sketchpad has shown the most usefulness as an aid to the understanding of processes, such as the notion of linkages, which can be described with pictures. Sketchpad also makes it easy to draw highly repetitive or highly accurate drawings and to change
Construction of genetic linkage map in man using restriction fragment length polymorphisom
 Am. J. Hum Genet
"... We describe a new basis for the construction of a genetic linkage map of the human genome. The basic principle of the mapping scheme is to develop, by recombinant DNA techniques, random singlecopy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests of ..."
Abstract

Cited by 423 (1 self)
 Add to MetaCart
We describe a new basis for the construction of a genetic linkage map of the human genome. The basic principle of the mapping scheme is to develop, by recombinant DNA techniques, random singlecopy DNA probes capable of detecting DNA sequence polymorphisms, when hybridized to restriction digests
Graphical models, exponential families, and variational inference
, 2008
"... The formalism of probabilistic graphical models provides a unifying framework for capturing complex dependencies among random variables, and building largescale multivariate statistical models. Graphical models have become a focus of research in many statistical, computational and mathematical fiel ..."
Abstract

Cited by 800 (26 self)
 Add to MetaCart
The formalism of probabilistic graphical models provides a unifying framework for capturing complex dependencies among random variables, and building largescale multivariate statistical models. Graphical models have become a focus of research in many statistical, computational and mathematical
Bayes Factors
, 1995
"... In a 1935 paper, and in his book Theory of Probability, Jeffreys developed a methodology for quantifying the evidence in favor of a scientific theory. The centerpiece was a number, now called the Bayes factor, which is the posterior odds of the null hypothesis when the prior probability on the null ..."
Abstract

Cited by 1766 (74 self)
 Add to MetaCart
is onehalf. Although there has been much discussion of Bayesian hypothesis testing in the context of criticism of P values, less attention has been given to the Bayes factor as a practical tool of applied statistics. In this paper we review and discuss the uses of Bayes factors in the context of five
Tandem repeats finder: a program to analyze DNA sequences
, 1999
"... A tandem repeat in DNA is two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats have been shown to cause human disease, may play a variety of regulatory and evolutionary roles and are important laboratory and analytic tools. Extensive knowledge about pattern size, co ..."
Abstract

Cited by 946 (9 self)
 Add to MetaCart
repeats by percent identity and frequency of indels between adjacent pattern copies and use statistically based recognition criteria. We demonstrate the algorithm's speed and its ability to detect tandem repeats that have undergone extensive mutational change by analyzing four sequences: the human
Results 1  10
of
290,538