Bayesian spatial extreme value analysis to assess the

small fraction of patients with repetitive injuries

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functions, their large-scale structure is essentially unknown. Here we present the first systematic comparative mathematical analysis of the metabolic networks of 43 organisms representing all three domains of life. We show that, despite significant variances in their individual constituents and pathways

algorithm is implemented and the results are used to augment and critique the structure of a large hand-built thesaurus. Extensions and applications to areas such as information retrieval are suggested.

We are given a large database of customer transactions. Each transaction consists of items purchased by a customer in a visit. We present an efficient algorithm that generates all significant association rules between items in the database. The algorithm incorporates buffer management and novel

The problems of designing large software systems were studied through interviewing personnel from 17 large projects. A layered behavioral model is used to analyze how three lgf these problems-the thin spread of application domain knowledge, fluctuating and conflicting requirements

be computed quickly, making it suitable for large data sets. Our implementation, written for use in a large-scale 3D digitization project, launches quickly, maintains a user-settable interactive frame rate regardless of object complexity or camera position, yields reasonable image quality during motion

ation, and termination phases of protein synthesis. Because the structures of several DNA and RNA polymerases have been determined at atomic resolution, the mechanisms of DNA and RNA synthesis are both well understood. Determination of the structure of the ribosome, however, has proven a daunting task. It is several times larger than the largest polymerase, and 100 times larger than lysozyme, the first enzyme to be understood at atomic resolution. Until now an atomic resolution structure for the ribosome has not been available, and as a result the mechanism of protein synthesis has remained a mystery. Electron microscopy has contributed to our understanding of ribosome structure ever since the ribosome was discovered. In the last few years, three-dimensional (3D) electron microscopic images of the ribosome have been produced at resolutions sufficiently high to visualize many of the proteins and nucleic acids that assist in protein synthesis bound to the ribosome (3). Earlier this yea

A large portion of real-world data is stored in commercial relational database systems. In contrast, most statistical learning methods work only with "flat " data representations. Thus, to apply these methods, we are forced to convert our data into a flat form, thereby losing much