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Tumor pathogenesis of human neurotropic JC virus in the CNS

by Gary L Gallia, Jennifer Gordon, Kamel Khalili , 1998
"... In the last several years, studies have reported the detection of sequences similar to the polyomavirus, Simian Virus 40 (SV40) in human tumors including choroid plexus papillomas and ependymomas. Taken together with well-established evidence that SV40, as well as the human polyomaviruses JC virus ( ..."
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In the last several years, studies have reported the detection of sequences similar to the polyomavirus, Simian Virus 40 (SV40) in human tumors including choroid plexus papillomas and ependymomas. Taken together with well-established evidence that SV40, as well as the human polyomaviruses JC virus

Human neurotropic JC virus and its association with brain tumors

by Kamel Khalili - Dis Markers , 2001
"... JC virus (JCV) is a human polyomavirus known as the causative agent of the fatal demyelinating disease, Progres-sive Multifocal Leukoencephalopathy (PML). Further, in ex-perimental animals this virus causes a broad range of tumors of central nervous system origin. Recent studies have sug-gested the ..."
Abstract - Cited by 1 (1 self) - Add to MetaCart
JC virus (JCV) is a human polyomavirus known as the causative agent of the fatal demyelinating disease, Progres-sive Multifocal Leukoencephalopathy (PML). Further, in ex-perimental animals this virus causes a broad range of tumors of central nervous system origin. Recent studies have sug

syndrome. Acta Onco / 1993:32:197—201.

by Is. Simpson, Vinik Al, Harangos Pj, Lloyd Rv. Immunohistochemical Localization Of
"... 6. Kvols LK, Reubi JC. Metastaticcarcinoid tumors and the malignant carcinoid ..."
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6. Kvols LK, Reubi JC. Metastaticcarcinoid tumors and the malignant carcinoid

T ′ proteins influence JC virus biology

by Richard J Frisque, Brigitte Bollag, Shiva K Tyagarajan, Lisa H Kilpatrick
"... The JC virus early mRNA is alternatively spliced to yield five transcripts that encode large T antigen, small t antigen, T ′ 135,T ′ 136, and T ′ 165. The splicing process is regulated differentially in transformed versus lytically infected cells and temporally during the course of a productive infe ..."
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The JC virus early mRNA is alternatively spliced to yield five transcripts that encode large T antigen, small t antigen, T ′ 135,T ′ 136, and T ′ 165. The splicing process is regulated differentially in transformed versus lytically infected cells and temporally during the course of a productive

Treadmill Training Following Surgical Removal of a Spinal Tumor in Infancy

by Jill C. Heathcock, Catie Christensen, Karah Bush, Marisa Butler, Jeffrey J. Buehner, D. Michele
"... [Heathcock JC, Christensen C, Bush K, et al. Treadmill training following surgical removal of a spinal tumor in infancy. Phys Ther. 2014;94:xxx–xxx.] ..."
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[Heathcock JC, Christensen C, Bush K, et al. Treadmill training following surgical removal of a spinal tumor in infancy. Phys Ther. 2014;94:xxx–xxx.]

A Potential Linkage Between the JC and BK Polyomaviruses and Brain and Urinary Tract Tumors: A Review of the Literature

by Silvia Carluccio, Lucia Signorini, Francesca Elia, Sonia Villani, Serena Delbue
"... ABSTR ACT: JC virus (JCV) and BK virus (BKV) belong to the Polyomaviridae family and were the first human polyomaviruses (PyVs) discovered. Both JCV and BKV remain latent in the kidneys and can reactivate in immunocompromised hosts, causing progressive multifocal leukoencephalopathy (PML) and nephro ..."
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ABSTR ACT: JC virus (JCV) and BK virus (BKV) belong to the Polyomaviridae family and were the first human polyomaviruses (PyVs) discovered. Both JCV and BKV remain latent in the kidneys and can reactivate in immunocompromised hosts, causing progressive multifocal leukoencephalopathy (PML

Prevalence of JC Virus in Chinese Patients with Colorectal Cancer

by Xiaozhou Mou, Ling Chen, Fanlong Liu, Jian Lin, Pingping Diao, Haohao Wang, Yifei Li, Jianjiang Lin, Lisong Teng, Charlie Xiang
"... Background: JCV is a DNA polyomavirus very well adapted to humans. Although JCV DNA has been detected in colorectal cancers (CRC), the association between JCV and CRC remains controversial. In China, the presence of JCV infection in CRC patients has not been reported. Here, we investigated JCV infec ..."
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infection and viral DNA load in Chinese CRC patients and to determine whether the JCV DNA in peripheral blood (PB) can be used as a diagnostic marker for JCV-related CRC. Methodology/Principal Findings: Tumor tissues, non-cancerous tumor-adjacent tissues and PB samples were collected from 137 CRC patients

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by Luis Del Valle, Jin Ying Wang, Adam Lassak, Francesca Peruzzi, Sidney Croul, Kamel Khalili, Krzysztof Reiss
"... Insulin-like growth factor I receptor signaling system in JC virus T antigen–induced primitive neuroectodermal tumors—medulloblastomas ..."
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Insulin-like growth factor I receptor signaling system in JC virus T antigen–induced primitive neuroectodermal tumors—medulloblastomas

JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells

by Evan Noch, Ilker Kudret Sariyer, Jennifer Gordon, Kamel Khalili
"... Recent studies have reported the detection of the human neurotropic virus, JCV, in a significant population of brain tumors, including medulloblastomas. Accordingly, expression of the JCV early protein, T-antigen, which has transforming activity in cell culture and in transgenic mice, results in the ..."
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Recent studies have reported the detection of the human neurotropic virus, JCV, in a significant population of brain tumors, including medulloblastomas. Accordingly, expression of the JCV early protein, T-antigen, which has transforming activity in cell culture and in transgenic mice, results

Short Communication No Evidence of an Association of JC Virus

by Colon Neoplasia, Jeannette Bigler
"... JC virus (JCV) is an ubiquitous human polyomavirus that frequently resides in the kidneys of healthy individuals and is excreted in the urine of a large proportion of the adult population. Polyomaviruses are associated with disease largely in immunocompro-mised individuals (progressive multifocal le ..."
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JC virus (JCV) is an ubiquitous human polyomavirus that frequently resides in the kidneys of healthy individuals and is excreted in the urine of a large proportion of the adult population. Polyomaviruses are associated with disease largely in immunocompro-mised individuals (progressive multifocal
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