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doi:10.1093/ecam/nen068 Original Article Carthamus tinctorius Enhances the Antitumor Activity of
, 2008
"... Copyright © 2011 Jia-Ming Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Carthamus tinctorius (CT), also named safflowe ..."
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and the maturation of DCs in response to CT were analyzed. To assess the antitumor activity of CT extract on mouse CD117 + (c-kit)-derived DCs pulsed with JC mammal tumor antigens, the JC tumor was challenged by the CT-treated DC vaccine in vivo. CT stimulated IFN-γ and IL-10 secretion of splenic T lymphocytes
JC Virus T-Antigen Regulates Glucose Metabolic Pathways in Brain Tumor Cells
"... Recent studies have reported the detection of the human neurotropic virus, JCV, in a significant population of brain tumors, including medulloblastomas. Accordingly, expression of the JCV early protein, T-antigen, which has transforming activity in cell culture and in transgenic mice, results in the ..."
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Recent studies have reported the detection of the human neurotropic virus, JCV, in a significant population of brain tumors, including medulloblastomas. Accordingly, expression of the JCV early protein, T-antigen, which has transforming activity in cell culture and in transgenic mice, results
Human neurotropic JC virus and its association with brain tumors
- Dis Markers
, 2001
"... JC virus (JCV) is a human polyomavirus known as the causative agent of the fatal demyelinating disease, Progres-sive Multifocal Leukoencephalopathy (PML). Further, in ex-perimental animals this virus causes a broad range of tumors of central nervous system origin. Recent studies have sug-gested the ..."
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Cited by 1 (1 self)
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JC virus (JCV) is a human polyomavirus known as the causative agent of the fatal demyelinating disease, Progres-sive Multifocal Leukoencephalopathy (PML). Further, in ex-perimental animals this virus causes a broad range of tumors of central nervous system origin. Recent studies have sug
T ′ proteins influence JC virus biology
"... The JC virus early mRNA is alternatively spliced to yield five transcripts that encode large T antigen, small t antigen, T ′ 135,T ′ 136, and T ′ 165. The splicing process is regulated differentially in transformed versus lytically infected cells and temporally during the course of a productive infe ..."
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The JC virus early mRNA is alternatively spliced to yield five transcripts that encode large T antigen, small t antigen, T ′ 135,T ′ 136, and T ′ 165. The splicing process is regulated differentially in transformed versus lytically infected cells and temporally during the course of a productive
unknown title
"... Insulin-like growth factor I receptor signaling system in JC virus T antigen–induced primitive neuroectodermal tumors—medulloblastomas ..."
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Insulin-like growth factor I receptor signaling system in JC virus T antigen–induced primitive neuroectodermal tumors—medulloblastomas
NF2, Induces Proteasome-Mediated Degradation of JC Virus T-Antigen in Human Glioblastoma
"... Neurofibromatosis type 2 protein (NF2) has been shown to act as tumor suppressor primarily through its functions as a cytoskeletal scaffold. However, NF2 can also be found in the nucleus, where its role is less clear. Previously, our group has identified JC virus (JCV) tumor antigen (T-antigen) as a ..."
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Neurofibromatosis type 2 protein (NF2) has been shown to act as tumor suppressor primarily through its functions as a cytoskeletal scaffold. However, NF2 can also be found in the nucleus, where its role is less clear. Previously, our group has identified JC virus (JCV) tumor antigen (T-antigen
PROPERTIES OF THE CAUSATIVE AGENT OF A CHICKEN TUMOR V. ANTIGENIC PROPERTIES OF THE CHICKEN TUMOR I*
, 1932
"... In the early investigations into the nature of the etiologic agent of fowl tumors, immunity phenomena were given some attention. The first observation was that the manifestations of resistance to these tumors in fowls, whether natural or acquired, are similar to those established for mammalian tumor ..."
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tumors, the principal feature being a local cellular reaction about the introduced graft (1). As was also established for mammals, the transfer of large mounts of blood or serum from resistant animals had no influence on the growth of established tumors in susceptible ones. Later results indicated
Interaction and co-localization of JC virus large T antigen and the F-box protein β-transducin-repeat containing protein
"... Lytic infection and transformation of cultured cells by JC virus (JCV) require five tumor proteins, which interact with factors regulating critical cellular processes. We demonstrate that JCV large T antigen (TAg) binds the F-box proteins β-transducin-repeat containing protein-1 and 2 (βTrCP1/2). Th ..."
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Lytic infection and transformation of cultured cells by JC virus (JCV) require five tumor proteins, which interact with factors regulating critical cellular processes. We demonstrate that JCV large T antigen (TAg) binds the F-box proteins β-transducin-repeat containing protein-1 and 2 (βTrCP1
Insights into the Initiation of JC Virus DNA Replication Derived from the Crystal Structure of the T-Antigen Origin Binding Domain
, 2014
"... JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a disease that occurs primarily in people who are immunocompromised and is usually fatal. As with other Polyomavirus family members, the replicatio ..."
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JC virus is a member of the Polyomavirus family of DNA tumor viruses and the causative agent of progressive multifocal leukoencephalopathy (PML). PML is a disease that occurs primarily in people who are immunocompromised and is usually fatal. As with other Polyomavirus family members
A Potential Linkage Between the JC and BK Polyomaviruses and Brain and Urinary Tract Tumors: A Review of the Literature
"... ABSTR ACT: JC virus (JCV) and BK virus (BKV) belong to the Polyomaviridae family and were the first human polyomaviruses (PyVs) discovered. Both JCV and BKV remain latent in the kidneys and can reactivate in immunocompromised hosts, causing progressive multifocal leukoencephalopathy (PML) and nephro ..."
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) and nephropathy, respectively. PyVs induce cell transformation in vitro and in animal models, where they infect non-permissive cells. The molecular mecha-nisms of tumor formation are based on the large tumor antigen (T Ag) protein, which is able to bind and inactivate pRb and p53, inducing uncontrolled cell cycle
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