Results 11 - 20
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193
Pattern formation by local self-activation and lateral inhibition
- BioEssays
, 2000
"... In 1972, we proposed a theory of biological pattern formation in which concentration maxima of pattern forming substances are generated through local self-enhancement in conjunction with long range inhibition. Since then, much evidence in various developmental systems has confirmed the importance of ..."
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Cited by 89 (1 self)
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of autocatalytic feedback loops combined with inhibitory interaction. Examples are found in the formation of embryonal organizing regions, in segmentation, in the polarization of individual cells, and in gene activation. By computer simulations, we have shown that the theory accounts for much of the regulatory
PREVALENCE OF RECTOANAL INHIBITORY REFLEX IN CHAGASIC MEGACOLON
"... ABSTRACT – Background- Rectoanal inhibitory reflex is not always evident in patients with chagasic megacolon. This may be due to insufficient volumes of air used during insufflation for the manometric examination. Aims- To identify the volume of air necessary to induce rectoanal inhibitory reflex in ..."
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reflex. Results- Rectoanal inhibitory reflex was identified in 43.6 % of the patients using a mean volume of 196 mL of insufflated air (standard error = 13.5). Conclusion- Rectoanal inhibitory reflex can be induced in patients with chagasic megacolon when greater volumes of air are used. HEADINGS
Impaired error awareness and anterior cingulate cortex hypoactivity in chronic cannabis users
- Neuropsychopharmacology
, 2009
"... Drug abuse and other psychiatric conditions (eg, schizophrenia) have been associated with a diminished neural response to errors, particularly in the anterior cingulate cortex (ACC) thought critical to error processing. A diminished capacity for detecting errors has been linked to clinical symptoms ..."
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Cited by 24 (3 self)
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including the loss of insight, delusions, and perseverative behavior. A total of 16 active chronic cannabis users and 16 control participants were administered a Go/No-go response inhibition task during event-related fMRI data collection. The task provides measures of inhibitory control and error awareness
Cerebral Cortex doi:10.1093/cercor/bhp225 Immaturities in Reward Processing and Its Influence on Inhibitory Control in Adolescence
"... The nature of immature reward processing and the influence of rewards on basic elements of cognitive control during adolescence are currently not well understood. Here, during functional magnetic resonance imaging, healthy adolescents and adults performed a modified antisaccade task in which trial-b ..."
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inhibitory responses across ages and in fewer inhibitory errors in adolescents. During reward trials, the blood oxygen level--dependent signal was attenuated in the ventral striatum in adolescents during cue assessment, then overactive during response preparation, suggesting limitations during adolescence
Post-error behavior in active cocaine users: poor awareness of errors in the presence of intact performance adjustments. Neuropsychopharmacology 32
, 2007
"... Active cocaine abusers have a diminished neural response to errors, particularly in the anterior cingulate cortex thought critical to error processing. The inability to detect, or adjust performance following errors has been linked to clinical symptoms including the loss of insight and perseverative ..."
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Cited by 9 (1 self)
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subjects, mean 39.9) participated. The results indicated that cocaine users consistently demonstrated poorer inhibitory control, a deficit accompanied by reduced awareness of errors. Adaptation of post-error reaction times did not differ between groups, although a different measure of adaptive behavior
High-potency marijuana impairs executive function and inhibitory motor control.
- Neuropsychopharmacology
, 2006
"... Human performance studies have usually relied on low-potency marijuana (4% THC) for determining THC-induced impairment. The present study was designed to assess the effects of high-potency marijuana (13% THC) on human performance. In all, 20 recreational users of marijuana participated in a double- ..."
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Cited by 15 (2 self)
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and the proportions of commission and omission errors in the Stop signal task. THC-induced impairments lasted up to 6 h postsmoking as indicated by the absence of a THC Â Time after smoking interaction. Effect sizes for performance impairments produced by THC 250 mg/kg were relatively low but generally increased by a
Prediction of PKCθ inhibitory activity using the random forest algorithm
- Int. J. Mol. Sci
"... Abstract: This work is devoted to the prediction of a series of 208 structurally diverse PKCθ inhibitors using the Random Forest (RF) based on the Mold 2 molecular descriptors. The RF model was established and identified as a robust predictor of the experimental pIC50 values, producing good external ..."
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Cited by 2 (2 self)
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external R 2 pred of 0.72, a standard error of prediction (SEP) of 0.45, for an external prediction set of 51 inhibitors which were not used in the development of QSAR models. By using the RF built-in measure of the relative importance of the descriptors, an important predictor—the number of group donor
Simulating individual word identification thresholds and errors in the fragmentation task
- Memory & Cognition
, 1998
"... This article presents a large-scale study that collected word identification thresholds and errors in the fragmentation task for all four-letter French words. In the first part of this article, we identify some of the variables (e.g., word frequency, neighborhood size, letter confusability) that aff ..."
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Cited by 10 (3 self)
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–letter feedback and letter– word inhibition. In the third part, we demonstrate that the adaptation of the interactive activation model to the fragmentation task makes it possible to successfully simulate a facilitatory frequency effect on identification thresholds, an inhibitory neighborhood size effect on error
Cerebellar Substrates for Error Correction in Motor Conditioning
"... The authors evaluate a mapping of Rescorla and Wagner’s (1972) behavioral model of classical conditioning onto the cerebellar substrates for motor reflex learning and illustrate how the limitations of the Rescorla–Wagner model are just as useful as its successes for guiding the development of new ps ..."
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psychobiological theories of learning. They postulate that the inhibitory pathway that returns condi-tioned response information from the cerebellar interpositus nucleus back to the inferior olive is the neural basis for the error correction learning proposed by Rescorla and Wagner (Gluck, Myers, & Thompson
Bayesian neural adjustment of inhibitory control predicts emergence of problem stimulant use
"... *These authors contributed equally to this work. Bayesian ideal observer models quantify individuals' context-and experience-dependent beliefs and expectations about their environment, which provides a powerful approach (i) to link basic behavioural mechanisms to neural processing; and (ii) to ..."
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) to generate clinical predictors for patient populations. Here, we focus on (ii) and determine whether individual differences in the neural representation of the need to stop in an inhibitory task can predict the development of problem use (i.e. abuse or dependence) in individuals experimenting with stimulants
Results 11 - 20
of
193