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of Medicine, Intern CORRESPONDENCE

by Özer Ûehirli
"... Despite considerable progress in the manage-ment of burn care, systemic inflammatory re-sponse syndrome, sepsis, and multiple organ failure still continue to be a leading cause of mor- ..."
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Despite considerable progress in the manage-ment of burn care, systemic inflammatory re-sponse syndrome, sepsis, and multiple organ failure still continue to be a leading cause of mor-

unknown title

by unknown authors
"... Sepsis and its complications continue to represent a significant cause of mortality among hospitalized patients. It includes a systemic inflammatory re-sponse to infection and when associated with organ ..."
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Sepsis and its complications continue to represent a significant cause of mortality among hospitalized patients. It includes a systemic inflammatory re-sponse to infection and when associated with organ

Effects of Composite Restorations on the Periodontal Membrane in Monkeys

by C. E. Nasjleti, W. A. Castelli, R. G. Caffesse
"... We evaluated the histopathological response of the periodontal membrane to intentionally-replanted teeth carrying composite (ex-perimental) and silver amalgam (control) restorations in the middle third of each root. The study revealed that the amnlgam produced, in the periodontal tissues, an initial ..."
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, an initial localized inflammation that subsided with the subsequent formation of a fibrous capsule. However, the periodontal membrane adjacent to the composite resin restorations demonstrated chronic inflammation. It was concluded that the composite evoked chronic inflammatory re-sponses of the periodontal

In Vitro Evaluation of the Effects of Low-Intensity Nd:YAG Laser Irradiation on the Inflammatory Reaction Elicited by Bacterial Lipopolysaccharide Adherent to Titanium Dental Implants

by Marco Giannelli, Daniele Bani, Alessia Tani, Ro Pini, Martina Margheri, Ra Zecchi-orl, Paolo Tonelli, Lucia Formigli, Key Words
"... (LPS) represents a prime pathogenic factor of peri-implantitis because of its ability to adhere tenaciously to dental titanium implants. Despite this, the current therapeutic approach to this disease remains based mainly on bacterial decontamina-tion, paying little attention to the neutralization of ..."
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of bioactive bacterial products. The purpose of the present study was to evaluate whether irradiation with low-energy neodymium-doped:yttrium, aluminum, and garnet (Nd:YAG) laser, in addi-tion to the effects on bacterial implant decontamination, was capable of attenuating the LPS-induced inflammatory re-sponse

RESEARCH Predicting treatment failu u e

by unknown authors
"... Full list of author information is available at the end of the articleproblem worldwide. Clinically, CAP exhibits enormous variety in the severity of presentation, from septic shock at one end of the spectrum to almost asymptomatic disease at the other [1]. Treatment failure is a matter of great con ..."
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]. Conversely, an exaggerated anti-inflammatory re-sponse conducted by some grade of impaired immune response may have a negative effect on clinical resolution [4]. Among the cytokines involved in the inflammatory re-sponse, we can include interleukin 10 (IL-10) as a critical anti-inflammatory cytokine

Original Article Anti-Inflammatory Effects of the Advanced Glycation End Product Inhibitor LR-90 in Human Monocytes

by James L. Figarola, Narkunaraja Shanmugam, Rama Natarajan, Samuel Rahbar
"... their receptor (RAGE) plays an important role in the development of various diabetes complications, including atherosclerosis. Monocyte activation, adhesion, and migra-tion are key events in the pathogenesis of atherosclerosis. Previous studies showed that AGEs and S100b, a specific RAGE ligand, cou ..."
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, could augment monocyte inflammatory re-sponses via RAGE. In this study, we examined whether LR-90, a compound belonging to a new class of AGE inhib-itor, could inhibit inflammatory responses in human mono-cytes. Human THP-1 cells were pretreated with LR-90 and then stimulated with S100b. LR-90

Brewing complications: the effect of acute ethanol exposure on wound healing

by Katherine A. Radek, Matthew J. Ranzer, Luisa A. Dipietro , 2009
"... Ethanol consumption is linked to a higher incidence of traumatic wounds and increases the risk for morbidity and mortality following surgical or traumatic injury. One of the most profound effects of acute ethanol exposure on wound healing occurs during the inflammatory re-sponse, and altered cytokin ..."
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Ethanol consumption is linked to a higher incidence of traumatic wounds and increases the risk for morbidity and mortality following surgical or traumatic injury. One of the most profound effects of acute ethanol exposure on wound healing occurs during the inflammatory re-sponse, and altered

Management of haemorrhage in major trauma

by C Gaunt, Frca Ramc, Twoolley Frca Ramc
"... Major trauma is a significant cause of death worldwide, leading to 5 million deaths annually. A large proportion of deaths are due to bleeding, with haemorrhage accounting for 80 % of deaths in the operating theatre and 40 % of all deaths from trauma within the UK.1 Treatment approaches to the manag ..."
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to the management of major haemorrhage have transformed during recent decades, based mainly on retrospective evidence. Contemporary approaches emphasize rapid control of bleeding, early management of coagulopathy, maintenance of adequate perfu-sion, and minimizing the inflammatory re-sponse.2 Developments

Surgical stress: the role of pain and analgesia

by H. Kehlet - Br J Anaesth , 1989
"... The endocrine, metabolic and inflammatory re-sponses to injury and infection are composed of a variety of physiological changes often grouped together and called the surgical stress response. Over the past few decades, detailed knowledge has accumulated on this response and has allowed consideration ..."
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The endocrine, metabolic and inflammatory re-sponses to injury and infection are composed of a variety of physiological changes often grouped together and called the surgical stress response. Over the past few decades, detailed knowledge has accumulated on this response and has allowed

Real-time free cortisol quantification among critically ill children

by unknown authors
"... Stress from critical illness acti-vates a neurogenic – endocri-ne–inflammatory response, in-cluding activation of the hypothalamic–pituitary–adrenal axis re-sulting in increased cortisol production (1, 2). Cortisol plays a key role in the compensatory anti-inflammatory re-sponse syndrome in the sett ..."
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Stress from critical illness acti-vates a neurogenic – endocri-ne–inflammatory response, in-cluding activation of the hypothalamic–pituitary–adrenal axis re-sulting in increased cortisol production (1, 2). Cortisol plays a key role in the compensatory anti-inflammatory re-sponse syndrome
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