Pfam is a comprehensive collection of protein domains and families, represented as multiple sequence alignments and as profile hidden Markov models. The current release of Pfam (22.0) contains 9318 protein families. Pfam is now based not only on the UniProtKB sequence database, but also on NCBI Gen

Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described. Other recent innovations

This work focuses on algorithms which learn from examples to perform multiclass text and speech categorization tasks. Our approach is based on a new and improved family of boosting algorithms. We describe in detail an implementation, called BoosTexter, of the new boosting algorithms for text

the strengths and weaknesses of the wrapper approach andshow a series of improved designs. We compare the wrapper approach to induction without feature subset selection and to Relief, a filter approach to feature subset selection. Significant improvement in accuracy is achieved for some datasets for the two

_SIM for a rate of false positives of 10%. Approxi-mately half of the improvement over the profile–profile com-parison methods is attributable to the use of profile HMMs in place of simple profiles. Alignment quality: Higher sensitivity is mirrored by an in-creased alignment quality. HHsearch produced 1.2, 1

The Internet could change the lives of average citizens as much as did the telephone in the early part of the 20th century and television in the 1950s and 1960s. Researchers and social critics are debating whether the Internet is improving or harming participation in community life and social

This paper reviews the literature on men and family planning in Bangladesh. A variety of topics are covered: male fertility preferences, male KAP, opinions about male methods of contraception, family planning decision-making, and recent efforts to involve Bangladeshi men in family planning programs

Full list of author information is available at the end of the articleBackground When an individual (proband) receives a new diagnosis of a genetic condition for themselves or their child, the genetic information often has implications for other family members who may themselves be at risk

We propose a family of constant-degree routing networks of logarithmic diameter, with the additional property that the addition or removal of a node to the network requires no global coordination, only a constant number of linkage changes in expectation, and a logarithmic number with high

This paper presents a new algorithm for mobile robot localization, called Monte Carlo Localization (MCL). MCL is a version of Markov localization, a family of probabilistic approaches that have recently been applied with great practical success. However, previous approaches were either