Pfam is a comprehensive collection of protein domains and families, represented as multiple sequence alignments and as profile hidden Markov models. The current release of Pfam (22.0) contains 9318 protein families. Pfam is now based not only on the UniProtKB sequence database, but also on NCBI Gen

Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described. Other recent innovations

of probability distributions — are best studied in the general setting. Working with exponential family representations, and exploiting the conjugate duality between the cumulant function and the entropy for exponential families, we develop general variational representations of the problems of computing

This work focuses on algorithms which learn from examples to perform multiclass text and speech categorization tasks. Our approach is based on a new and improved family of boosting algorithms. We describe in detail an implementation, called BoosTexter, of the new boosting algorithms for text

The accuracy of multiple sequence alignment pro-gram MAFFT has been improved. The new version (5.3) of MAFFT offers new iterative refinement opti-ons, H-INS-i, F-INS-i and G-INS-i, in which pairwise alignment information are incorporated into objective function. These new options of MAFFT showed

improvement. Investigators and editors developed the original CONSORT (Consolidated Standards of Reporting Trials) statement to help authors improve reporting by using a checklist and flow diagram. The revised CONSORT statement presented in this paper incorporates new evidence and addresses some criticisms

Weitzman have improved this paper. I thank NSF for financial

We examine the separation of ownership and control for 2,980 corporations in nine East Asian countries. In all countries, voting rights frequently exceed cash-#ow rights via pyramid structures and cross-holdings. The separation of ownership and control is most pronounced among family

the strengths and weaknesses of the wrapper approach andshow a series of improved designs. We compare the wrapper approach to induction without feature subset selection and to Relief, a filter approach to feature subset selection. Significant improvement in accuracy is achieved for some datasets for the two

of nonmonotonic reasoning and try to isolate properties that could help us map the field of nonmonotonic reasoning by reference to positive properties. We concentrate on a number of families of nonmonotonic consequence relations, defined in the style of Gentzen [13]. Both proof-theoretic and semantic points