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Modeling and simulation of genetic regulatory systems: A literature review

by Hidde De Jong - JOURNAL OF COMPUTATIONAL BIOLOGY , 2002
"... In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between ..."
Abstract - Cited by 738 (14 self) - Add to MetaCart
In order to understand the functioning of organisms on the molecular level, we need to know which genes are expressed, when and where in the organism, and to which extent. The regulation of gene expression is achieved through genetic regulatory systems structured by networks of interactions between

KEGG: Kyoto Encyclopedia of Genes and Genomes

by Hiroyuki Ogata, Susumu Goto, Kazushige Sato, Wataru Fujibuchi, Hidemasa Bono - Nucl. Acids Res , 1999
"... Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules. The major component of KEGG is the PATHWAY database that consists of graphical diagrams of biochemical pathways including most of the known me ..."
Abstract - Cited by 408 (0 self) - Add to MetaCart
Kyoto Encyclopedia of Genes and Genomes (KEGG) is a knowledge base for systematic analysis of gene functions in terms of the networks of genes and molecules. The major component of KEGG is the PATHWAY database that consists of graphical diagrams of biochemical pathways including most of the known

Real-time quantification of microRNAs by stem-loop RT-PCR

by Caifu Chen, Dana A. Ridzon, Adam J. Broomer, Zhaohui Zhou, Danny H. Lee, Julie T. Nguyen, Maura Barbisin, Nan Lan Xu, Vikram R. Mahuvakar, Mark R. Andersen, Kai Qin Lao, Kenneth J. Livak, Karl J. Guegler - Nucleic Acids Res , 2005
"... A novel microRNA (miRNA) quantification method has been developed using stem–loop RT followed by TaqMan PCR analysis. Stem–loop RT primers are better than conventional ones in terms of RT efficiency and specificity. TaqMan miRNA assays are specific for mature miRNAs and discriminate among related mi ..."
Abstract - Cited by 394 (8 self) - Add to MetaCart
cell. This method enables fast, accurate and sensitive miRNA expression profiling and can identify and monitor potential biomarkers specific to tissues or diseases. Stem–loop RT–PCR can be used for the quantification of other small RNA molecules such as short interfering RNAs (siRNAs). Furthermore

the review on

by Manoj Kumar Pandey, Æ Reena Rani, Æ Suraksha Agrawal, Immunotherapy Æ Immunoglobulin (ivig - D0 −D0 Mixing” in this Review
"... Abstract Recurrent spontaneous abortion (RSA) is de-fined as three or more consecutive pregnancy losses prior to the 20th week of gestation. The etiology of recurrent spontaneous abortion is often unclear and may be multifactorial, with much controversy regarding diag-nosis and treatment. Reasonably ..."
Abstract - Cited by 361 (4 self) - Add to MetaCart
-Bf) antibodies that may play major role in the immunologic failure of pregnancy and may lead to abortion. Alter-ation in the expression of HLA-G molecules, T-helper-1 (Th-1) pattern of cytokines and natural killer (NK) cells activity may also induce abortion. Various forms of treatment like antithrombotic

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: down-regulation by cytokines and bacterial products.J. Exp. Mecl

by Federica Sallusto, R Marina Cella, Carlo Danieli, Antonio , 1995
"... We have previously demonstrated that human peripheral blood low density mononuclear cells cultured in granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4 develop into dendritic cells (DCs) that are extremely efficient in presenting soluble antigens to T ceils. To identif ..."
Abstract - Cited by 334 (8 self) - Add to MetaCart
uptake via macropinocytosis. In contrast to what has been found with other cell types, macropinocytosis in DCs is constitutive and allows continuous internalization of large volumes of fluid. The second mechanism of capture is mediated via the mannose receptor (MR), which is expressed at high levels

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role

by Simon Read, Vivianne Malmström, Fiona Powrie - in the function of CD25 � CD4 , 2000
"... It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both self- and intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same p ..."
Abstract - Cited by 224 (9 self) - Add to MetaCart
It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the normal immune repertoire, preventing the development of pathogenic responses to both self- and intestinal antigens. Here, we report that the Treg cells that control intestinal inflammation express the same

Double muscling in cattle due to mutations in the myostatin gene

by Alexandra C Mcpherron , Se-Jin Lee - Proc. Natl Acad. Sci. USA , 1997
"... ABSTRACT Myostatin (GDF-8) is a member of the transforming growth factor ␤ superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass in mice. Here we report the myostatin sequences of nine other vertebrate species and the identificati ..."
Abstract - Cited by 216 (4 self) - Add to MetaCart
which causes a frameshift that eliminates virtually all of the mature, active region of the molecule. The Piedmontese myostatin sequence contains a missense mutation in exon 3, resulting in a substitution of tyrosine for an invariant cysteine in the mature region of the protein. The similarity

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

by Kyosuke Haze, Hiderou Yoshida, Hideki Yanagi, Takashi Yura, Kazutoshi Mori - Mol. Biol. Cell , 1999
"... The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a ..."
Abstract - Cited by 206 (9 self) - Add to MetaCart
The unfolded protein response (UPR) controls the levels of molecular chaperones and enzymes involved in protein folding in the endoplasmic reticulum (ER). We recently isolated ATF6 as a candidate for mammalian UPR-specific transcription factor. We report here that ATF6 constitutively expressed as a

Immunology for Physicists

by Alan S. Perelson, Gerard Weisbuch - Reviews of Modern Physics , 1997
"... The immune system is a complex system of cells and molecules that can provide us with a basic defense against pathogenic organisms. Like the nervous system,... ..."
Abstract - Cited by 81 (0 self) - Add to MetaCart
The immune system is a complex system of cells and molecules that can provide us with a basic defense against pathogenic organisms. Like the nervous system,...

microRNAs as oncogenes and tumor suppressors.

by Baohong Zhang , Xiaoping Pan , George P Cobb , Todd A Anderson - Dev. Biol., , 2007
"... Abstract microRNAs (miRNAs) are a new class of non-protein-coding, endogenous, small RNAs. They are important regulatory molecules in animals and plants. miRNA regulates gene expression by translational repression, mRNA cleavage, and mRNA decay initiated by miRNA-guided rapid deadenylation. Recent ..."
Abstract - Cited by 189 (0 self) - Add to MetaCart
Abstract microRNAs (miRNAs) are a new class of non-protein-coding, endogenous, small RNAs. They are important regulatory molecules in animals and plants. miRNA regulates gene expression by translational repression, mRNA cleavage, and mRNA decay initiated by miRNA-guided rapid deadenylation. Recent
Results 1 - 10 of 21,051