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9,488
Rho GTPases and the actin cytoskeleton
- Science
, 1998
"... The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the b ..."
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Cited by 615 (4 self)
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). It was concluded that Rho acts as a molecular switch to control a signal trans-duction pathway that links membrane re-ceptors to the cytoskeleton. Rac, the next member of the Rho family to be analyzed, could be activated by a distinct set of ago-nists (for example, platelet-derived growth factor or insulin
The Retinoblastoma Protein and Cell-Cycle Control
- Cell
, 1995
"... pRB, the product of the retinoblastoma tumor suppressor gene, operates in the midst of the cell cycle clock appara-tus. Its main role is to act as a signal transducer connecting the cell cycle clock with the transcriptional machinery. In this role, pRB allows the clock to control the expression of b ..."
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Cited by 429 (5 self)
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pRB, the product of the retinoblastoma tumor suppressor gene, operates in the midst of the cell cycle clock appara-tus. Its main role is to act as a signal transducer connecting the cell cycle clock with the transcriptional machinery. In this role, pRB allows the clock to control the expression
Rho-stimulated contractility drives the formation of stress fibers and focal adhesions
- J. Cell Biol
, 1996
"... Abstract. Activated rhoA, a ras-related GTP-binding protein, stimulates the appearance of stress fibers, focal adhesions, and tyrosine phosphorylation in quiescent cells (Ridley, A.J., and A. Hall, 1992. Cell. 70:389-399). The pathway by which rho triggers these events has not been elucidated. Many ..."
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Cited by 309 (5 self)
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filaments (stress fibers). More than just sites of structural linkage between the ECM on the outside and the cytoskeleton on the inside, focal adhesions are regions of signal transduction. Components involved in multiple signal transduction pathways have been identified in focal adhesions (Hynes, 1992;
Endotoxin signal transduction in macrophages
, 1996
"... Abstract: Through its action on macrophages, bac-terial lipopolysaccharide (LPS) or endotoxm can trigger responses that are protective or injurious to the host. This review examines the effects of LPS on macrophages by following events from the cell sur-face to the nucleus. The involvement of protei ..."
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Cited by 72 (6 self)
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Abstract: Through its action on macrophages, bac-terial lipopolysaccharide (LPS) or endotoxm can trigger responses that are protective or injurious to the host. This review examines the effects of LPS on macrophages by following events from the cell sur-face to the nucleus. The involvement
Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite
"... Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro-inflammatory cytokin ..."
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Leishmania parasites have evolved sophisticated mechanisms to subvert macrophage immune responses by altering the host cell signal transduction machinery, including inhibition of JAK/STAT signalling and other transcription factors such as AP-1, CREB and NF-kB. AP-1 regulates pro
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
- Science
"... The vast majority of proteins that a cell secretes or displays on its surface first enter the endoplasmic reticulum (ER), where they fold and assemble. Only properly assembled proteins advance from the ER to the cell surface. To ascertain fidelity in protein folding, cells regulate the protein-foldi ..."
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Cited by 209 (7 self)
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-folding capacity in the ER according to need. The ER responds to the burden of unfolded proteins in its lumen (ER stress) by activating intracellular signal transduction pathways, collectively termed the unfolded protein response (UPR). Together, at least three mechanistically distinct branches of the UPR regulate
Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus
- Science
, 2000
"... The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have prov ..."
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Cited by 158 (1 self)
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The Wnt cell-cell signaling pathway plays a critical and evolutionarily conserved role in directing cell fates during embryogenesis. In addition, inappropriate activation of the Wnt signal transduction pathway plays a role in a variety of human cancers. Many recent studies of Wnt signaling have
MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor
, 1999
"... Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (L ..."
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Cited by 202 (17 self)
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associated with TLR4 on the cell surface and confers responsiveness to LPS. MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms. Key words: leucine-rich repeat • RP
Lipid Domain Structure of the Plasma Membrane 941
, 1997
"... Abstract. Lateral assemblies of glycolipids and cholesterol, “rafts, ” have been implicated to play a role in cellular processes like membrane sorting, signal transduction, and cell adhesion. We studied the structure of raft domains in the plasma membrane of non-polarized cells. Overexpressed plasma ..."
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Cited by 198 (8 self)
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Abstract. Lateral assemblies of glycolipids and cholesterol, “rafts, ” have been implicated to play a role in cellular processes like membrane sorting, signal transduction, and cell adhesion. We studied the structure of raft domains in the plasma membrane of non-polarized cells. Overexpressed
cell wall and cell signal transduction
"... One sentence summary: Review of the life cycle, cell wall components and cell signaling of Pneumocystis, an important cause of pneumonia in immunosuppressed individuals. Editor: Carol Munro Pneumocystis is a genus of ascomycetous fungi that are highly morbid pathogens in immunosuppressed humans and ..."
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One sentence summary: Review of the life cycle, cell wall components and cell signaling of Pneumocystis, an important cause of pneumonia in immunosuppressed individuals. Editor: Carol Munro Pneumocystis is a genus of ascomycetous fungi that are highly morbid pathogens in immunosuppressed humans
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