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Staphylococcus aureus Keratinocyte Invasion Is Dependent upon Multiple High-Affinity Fibronectin- Binding Repeats within FnBPA

by Andrew M. Edwards, Ursula Potter, Nicola A. G. Meenan, Jennifer R. Potts, Ruth C. Massey
"... Staphylococcus aureus is a commensal organism and a frequent cause of skin and soft tissue infections, which can progress to serious invasive disease. This bacterium uses its fibronectin binding proteins (FnBPs) to invade host cells and it has been hypothesised that this provides a protected niche f ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
both colonisation and skin infection are dependent upon the interaction of S. aureus with keratinocytes we hypothesised that this might select for FnBP function and thus composition of the FnBR region. Initial experiments revealed that S. aureus attachment to keratinocytes is rapid but does not require

Staphylococcus aureus Host Cell Invasion and Virulence in Sepsis is Facilitated by the Multiple Repeats within FnBPA. PLoS Pathog. 6(6): e1000964

by Andrew M. Edwards, Jennifer R. Potts, Elisabet Josefsson, Ruth C. Massey , 2010
"... Entry of Staphylococcus aureus into the bloodstream can lead to metastatic abscess formation and infective endocarditis. Crucial to the development of both these conditions is the interaction of S. aureus with endothelial cells. In vivo and in vitro studies have shown that the staphylococcal invasin ..."
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invasin FnBPA triggers bacterial invasion of endothelial cells via a process that involves fibronectin (Fn) bridging to a 5b 1 integrins. The Fn-binding region of FnBPA usually contains 11 non-identical repeats (FnBRs) with differing affinities for Fn, which facilitate the binding of multiple Fn molecules
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