Tools
Sorted by:
Try your query at:
 |
 |
 |
 |
 |
 |
Results 1 - 10
of
204
Highly efficient antigen targeting to M-DC81 dendritic cells via FccRIII/CD16-specific antibody conjugates
"... Conjugates of peptide antigens with antibodies specifically recognizing surface molecules on dendritic cells (DC) represent an attractive approach to target antigens to antigen-presenting cells (APC) for the induction of specific T cell responses. The present study evaluates the potential of M-DC81 ..."
Abstract
- Add to MetaCart
DC, a sub-population of professional APC in the blood, for an antibody-based vaccination strategy. We prepared, by chemical cross-linking, conjugates of peptide model antigens with antibodies directed against different cell surface molecules of DC. Antigen–peptide conjugates using an anti-CD16 (FccRIII
NEOPLASIA Antibody-drug conjugates targeted to CD79 for the treatment of
"... Targeting cytotoxic drugs to cancer cells using antibody–drug conjugates (ADCs), particularly those with stable linkers be-tween the drug and the antibody, could be an effective cancer treatment with low toxicity. However, for stable-linker ADCs to be effective, they must be internalized and degrade ..."
Abstract
- Add to MetaCart
Targeting cytotoxic drugs to cancer cells using antibody–drug conjugates (ADCs), particularly those with stable linkers be-tween the drug and the antibody, could be an effective cancer treatment with low toxicity. However, for stable-linker ADCs to be effective, they must be internalized
Short Communication Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker s
, 2015
"... Antibody drug conjugates are emerging as a powerful class of antitumor agents with efficacy across a range of cancers; therefore, understanding the disposition of this class of thera-peutic is crucial. Reported here is a method of enriching a specific organelle (lysosome) to understand the catabolis ..."
Abstract
- Add to MetaCart
Antibody drug conjugates are emerging as a powerful class of antitumor agents with efficacy across a range of cancers; therefore, understanding the disposition of this class of thera-peutic is crucial. Reported here is a method of enriching a specific organelle (lysosome) to understand
Article Antibody-Conjugated Paramagnetic Nanobeads: Kinetics of Bead-Cell Binding
, 2014
"... Abstract: Specific labelling of target cell surfaces using antibody-conjugated paramagnetic nanobeads is essential for efficient magnetic cell separation. However, studies examining parameters determining the kinetics of bead-cell binding are scarce. The present study determines the binding rates fo ..."
Abstract
- Add to MetaCart
Abstract: Specific labelling of target cell surfaces using antibody-conjugated paramagnetic nanobeads is essential for efficient magnetic cell separation. However, studies examining parameters determining the kinetics of bead-cell binding are scarce. The present study determines the binding rates
A Comparison of 4 Radionuclides Conjugated to Antibodies for Single-Cell Kill
"... We previously found that 67Ga was more potent and more specific in single-cell kill than other Auger electron emitters and -particle emitters, using an anti-CD74 antibody (Ab) (major histocompatibility complex [MHC] class II invariant chain). Be-cause anti-CD74 Abs follow an unusual processing pathw ..."
Abstract
-
Cited by 1 (0 self)
- Add to MetaCart
We previously found that 67Ga was more potent and more specific in single-cell kill than other Auger electron emitters and -particle emitters, using an anti-CD74 antibody (Ab) (major histocompatibility complex [MHC] class II invariant chain). Be-cause anti-CD74 Abs follow an unusual processing
Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses
, 1970
"... The introduction of defned haptenic determinants into immunogenic carriers by Landsteiner (1) has provided a poweriul tool for the analysis of specific interactions between antigens and specific ceils in the immune response. Considerable evidence has been obtained demonstrating that cellular immune ..."
Abstract
-
Cited by 51 (15 self)
- Add to MetaCart
was initially interpreted to reflect the partial specificity of the antigen-binding receptors of specific cells for the carrier molecule (12-16), paralleling the demonstrated carrier specificity of anfi-hapten humoral antibodies (16-18). This interpretation of carrier function, however, is not able to explain
The immune response against hapten-autologous protein conjugates in the mouse. I. Specificity of antibodies produced during the primary
- SPECI~'ICIT¥ OF B AND T LYMPHOCYTES
, 1972
"... In order to achieve a deeper understanding of the regulation of the immune processes it is mandatory to further characterize the participants at the cellular and preferably also at the molecular level. Antibody formation frequently requires the collaboration between two types of lymphocytes where th ..."
Abstract
-
Cited by 7 (2 self)
- Add to MetaCart
thymus-processed lymphocytes (T cells) 1 can function as helpers for bursa-type lymphocytes (non-thymus-processed lymphocytes or B cells) to become induced into high-rate antibody synthesis (1-4). In this scheme both groups of lymphocytes can be shown to carry specific immunocompetence. The way through
Specific Intracellular Uptake of Herceptin-Conjugated CdSe/ZnS Quantum Dots into Breast Cancer Cells
"... Herceptin, a typical monoclonal antibody, was immobilized on the surface of CdSe/ZnS core-shell quantum dots (QDs) to enhance their specific interactions with breast cancer cells (SK-BR3). The mean size of the core-shell quantum dots (28 nm), as determined by dynamic light scattering, increased to ..."
Abstract
- Add to MetaCart
Herceptin, a typical monoclonal antibody, was immobilized on the surface of CdSe/ZnS core-shell quantum dots (QDs) to enhance their specific interactions with breast cancer cells (SK-BR3). The mean size of the core-shell quantum dots (28 nm), as determined by dynamic light scattering, increased
Research Article Specific Intracellular Uptake of Herceptin-Conjugated CdSe/ZnS Quantum Dots into Breast Cancer Cells
"... Copyright © 2014 Seung-Jin Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Herceptin, a typical monoclonal antibody, was i ..."
Abstract
- Add to MetaCart
, was immobilized on the surface of CdSe/ZnS core-shell quantum dots (QDs) to enhance their specific interactions with breast cancer cells (SK-BR3). The mean size of the core-shell quantum dots (28 nm), as determined by dynamic light scattering, increased to 86 nm after herceptin immobilization.The in vitro cell
Induction of Opsonophagocytic Killing Activity with Pneumococcal Conjugate Vaccine
"... The levels of IgG determined by ELISA may have limited relevance in human immunodeficiency virus (HIV)-infected adults because of nonfunctional antibodies. 58 HIV-1-infected and 29 HIV-uninfected Ugandan adults were immunized with conjugate vaccine (CV) followed by polysaccharide vaccine (PV) after ..."
Abstract
- Add to MetaCart
The levels of IgG determined by ELISA may have limited relevance in human immunodeficiency virus (HIV)-infected adults because of nonfunctional antibodies. 58 HIV-1-infected and 29 HIV-uninfected Ugandan adults were immunized with conjugate vaccine (CV) followed by polysaccharide vaccine (PV) after
Results 1 - 10
of
204
