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322
Fast multipoint linkage analysis and the program Allegro
"... The first two authors have contributed equally to this work ..."
Multipoint quantitativetrait linkage analysis in general pedigrees
 Am. J. Hum. Genet
, 1998
"... Multipoint linkage analysis of quantitativetrait loci (QTLs) has previously been restricted to sibships and small pedigrees. In this article, we show how variancecomponent linkage methods can be used in pedigrees of arbitrary size and complexity, and we develop a general framework for multipoint i ..."
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Cited by 567 (60 self)
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Multipoint linkage analysis of quantitativetrait loci (QTLs) has previously been restricted to sibships and small pedigrees. In this article, we show how variancecomponent linkage methods can be used in pedigrees of arbitrary size and complexity, and we develop a general framework for multipoint
Conventional Multipoint Nonparametric Linkage Analyses To the Editor:
"... We would like to comment on the Schork and Greenwood (2004) article dealing with the inherent “bias” toward the null hypothesis in the context of nonparametric linkage analysis. The authors point out that, in certain situations, a loss of evidence for linkage can result from the practice of assignin ..."
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We would like to comment on the Schork and Greenwood (2004) article dealing with the inherent “bias” toward the null hypothesis in the context of nonparametric linkage analysis. The authors point out that, in certain situations, a loss of evidence for linkage can result from the practice
Exact multipoint quantitativetrait linkage analysis in pedigrees by variance components
 Am. J. Hum. Genet
, 2000
"... Methods based on variance components are powerful tools for linkage analysis of quantitative traits, because they allow simultaneous consideration of all pedigree members. The central idea is to identify loci making a significant contribution to the population variance of a trait, by use of alleles ..."
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Cited by 6 (0 self)
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Methods based on variance components are powerful tools for linkage analysis of quantitative traits, because they allow simultaneous consideration of all pedigree members. The central idea is to identify loci making a significant contribution to the population variance of a trait, by use of allele
Sequential imputation and multipoint linkage analysis, Genetic Epidemiology 10: 483488
, 1993
"... A novel Monte Carlo method for linkage analyses involving large pedigrees and many polymorphic loci is introduced. Issues related to the efficiency of the method are discussed. CI 1993 WileyLiss, Inc. ..."
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Cited by 6 (1 self)
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A novel Monte Carlo method for linkage analyses involving large pedigrees and many polymorphic loci is introduced. Issues related to the efficiency of the method are discussed. CI 1993 WileyLiss, Inc.
Fast approximate polynomial multipoint evaluation and applications
, 2013
"... It is well known that, using fast algorithms for polynomial multiplication and division, evaluation of a polynomial F ∈ C[x] of degree n at n complexvalued points can be done with Õ(n) exact field operations in C, where Õ(·) means that we omit polylogarithmic factors. We complement this result by ..."
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Cited by 4 (2 self)
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by an analysis of approximate multipoint evaluation of F to a precision of L bits after the binary point and prove a bit complexity of Õ(n(L+ τ + nΓ)), where 2τ and 2Γ, with τ,Γ ∈ N≥1, are bounds on the magnitude of the coefficients of F and the evaluation points, respectively. In particular, in the important
Applying an Association Rule Discovery Algorithm to Multipoint Linkage Analysis
"... Knowledge discovery in large databases (KDD) is being performed in several application domains, for example, the analysis of sales data, and is expected to be applied to other domains. We propose a KDD approach to multipoint linkage analysis, which is a way of ordering loci on a chromosome. Strict m ..."
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Knowledge discovery in large databases (KDD) is being performed in several application domains, for example, the analysis of sales data, and is expected to be applied to other domains. We propose a KDD approach to multipoint linkage analysis, which is a way of ordering loci on a chromosome. Strict
Rapid Multipoint Linkage Analysis of Recessive Traits in Nuclear Families, including Homozygosity Mapping
"... this paper allows very rapid multipoint likelihood calculation in nuclear families (with or without parental consanguinity), and the accompanying software package makes multipoint mapping feasible in many experimental contexts. 18 18 Acknowledgments We thank David Botstein and Michele Gschwend for ..."
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Cited by 42 (0 self)
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this paper allows very rapid multipoint likelihood calculation in nuclear families (with or without parental consanguinity), and the accompanying software package makes multipoint mapping feasible in many experimental contexts. 18 18 Acknowledgments We thank David Botstein and Michele Gschwend
Fast Approximate Polynomial Multipoint Evaluation and Applications
, 2013
"... It is well known that, using fast algorithms for polynomial multiplication and division, evaluation of a polynomial F ∈ C[x] of degree n at n complexvalued points can be done with Õ(n) exact field operations in C, where Õ(·) means that we omit polylogarithmic factors. We complement this result by a ..."
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by an analysis of approximate multipoint evaluation of F to a precision of L bits after the binary point and prove a bit complexity of Õ(n(L + τ + nΓ)), where 2τ and 2Γ, with τ, Γ ∈ N≥1, are bounds on the magnitude of the coefficients of F and the evaluation points, respectively. In particular, in the important
Saturation multipoint linkage mapping of chromosome 6q in type 1 diabetes
 Hum. Mol. Genet
, 1996
"... Linkage analysis of type 1 diabetes sib pair families (n = 334) has suggested two separate regions of human chromosome 6q are linked to disease (designated IDDM5 and IDDM8). To test if these are false positive results, all available sib pair families (n = 429) were typed using a 92 % informative map ..."
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Cited by 4 (3 self)
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map of chromosome 6q and multipoint analysis. The two regions still showed positive evidence of linkage, most notably the proterminal region, 6q27, corresponding to IDDM8 (MLS = 2.57, p = 0.0006; λs = 1.17). In addition, some evidence of transmission disequilibrium was seen with marker a046xa9 (IDDM5).
Results 1  10
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322