individual and social environmental factors as targets for health promo-tion interventions. It addresses the importance of interventions directed at changing interpersonal, organizational, community, and public policy, factors which support and maintain unhealthy behaviors. The model assumes that appropriate

parties, officials, and scientists; complex, redundant, and layered institutions; a mix of institu-tional types; and designs that facilitate experimentation, learning, and change. In 1968, Hardin (1) drew attention to two human factors that drive environmental change. The first factor is the increasing de

Abstract-Instrumenting the physical world through large networks of wireless sensor nodes, particularly for applications like environmental monitoring of water and soil, requires that these nodes be very small, light, untethered and unobtrusive. The problem of localization, i.e., determining where

performance:the spatio-temporal characteristics of packet loss, and its environmental dependence. These factors will deeply impact the performance of data acquisition from these networks. In this paper, we report on a systematic medium-scale (up to sixty nodes) measurement of packet delivery in three

such as temperature, light, or seismic sensors with networking and computation capabilities. Applications range from environmental control, warehouse inventory, and health care to military environments. Existing sensor networks assume that the sensors are preprogrammed and send data to a central frontend where

in which hosts move less frequently. Based on results from a packet-level simulation of mobile hosts operating in an ad hoc network, the protocol performs well over a variety of environmental conditions such as host density and movement rates. For all but the highest rates of host movement simulated

and factors goveming their distribution Carbone organique Acides humiques

Voice and music education literature describe vocal stresses associated with vocal music teaching that may jeopardize vocal integrity. The purpose of this investigation was to systematically examine the predictive ability of three factors associated with professional voice use in elementary vocal

Type 1 (insulin-dependent) diabetes mellitus, like other organ specific autoimmune diseases, results from a disorder of immunoregulation. T cells specific for pancreatic islet 6 cell constituents (autoantigens) exist normally but are restrained by regulatory mechanisms (self-tolerant state). When regulation fails, t cell-specific autoreactive T cells become activated and expand clonally. Current evidence indicates that islet t cell-specific autoreactive T cells belong to a T helper 1 (Thl) subset, and these Thl cells and their characteristic cytokine products, IFN and IL-2, are believed to cause islet inflammation (insulitis) and tg cell destruction. Immune-mediated destruction of fg cells precedes hyperglycemia and clinical symptoms by many years because these become apparent only when most of the insulin-secreting fg cells have been destroyed. Therefore, several approaches are being tested or are under consideration for clinical trials to prevent or arrest complete autoimmune destruction of islet g cells and insulin-dependent diabetes. Approaches that attempt to correct underlying immunoregulatory defects in autoimmune diabetes include interventions aimed at i) deleting t cell autoreactive Thl cells and cytokines (IFN/and IL-2) and/or ii) increasing regulatory Th2 cells and/or Th3 cells and their cytokine products (IL-4, IL-10 and TGFfI).

Inaugural-Dissertation Zur Erlangung des Doktorgrades der Philosophie