The fused lasso was proposed recently to enable recovery of high-dimensional patterns which are piece-wise constant on a graph, by penalizing the 1-norm of differences of measurements at nodes that share an edge. While there have been some attempts at coming up with efficient algorithms for solving

implements the Lasso, an attractive version of ordinary least squares that constrains the sum of the absolute regression coefficients; the LARS modification calculates all possible Lasso estimates for a given problem, using an order of magnitude less computer time than previous methods. (2) A different LARS

The problem of efficient, interactive foreground/background segmentation in still images is of great practical importance in image editing. Classical image segmentation tools use either texture (colour) information, e.g. Magic Wand, or edge (contrast) information, e.g. Intelligent Scissors

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We consider the least-square regression problem with regularization by a block 1-norm, i.e., a sum of Euclidean norms over spaces of dimensions larger than one. This problem, referred to as the group Lasso, extends the usual regularization by the 1-norm where all spaces have dimension one, where

A full-rank matrix A ∈ IR n×m with n < m generates an underdetermined system of linear equations Ax = b having infinitely many solutions. Suppose we seek the sparsest solution, i.e., the one with the fewest nonzero entries: can it ever be unique? If so, when? As optimization of sparsity is combinatorial in nature, are there efficient methods for finding the sparsest solution? These questions have been answered positively and constructively in recent years, exposing a wide variety of surprising phenomena; in particular, the existence of easily-verifiable conditions under which optimally-sparse solutions can be found by concrete, effective computational methods. Such theoretical results inspire a bold perspective on some important practical problems in signal and image processing. Several well-known signal and image processing problems can be cast as demanding solutions of undetermined systems of equations. Such problems have previously seemed, to many, intractable. There is considerable evidence that these problems often have sparse solutions. Hence, advances in finding sparse solutions to underdetermined systems energizes research on such signal and image processing problems – to striking effect. In this paper we review the theoretical results on sparse solutions of linear systems, empirical

We consider the problem of estimating the parameters of a Gaussian or binary distribution in such a way that the resulting undirected graphical model is sparse. Our approach is to solve a maximum likelihood problem with an added ℓ1-norm penalty term. The problem as formulated is convex but the memory requirements and complexity of existing interior point methods are prohibitive for problems with more than tens of nodes. We present two new algorithms for solving problems with at least a thousand nodes in the Gaussian case. Our first algorithm uses block coordinate descent, and can be interpreted as recursive ℓ1-norm penalized regression. Our second algorithm, based on Nesterov’s first order method, yields a complexity estimate with a better dependence on problem size than existing interior point methods. Using a log determinant relaxation of the log partition function (Wainwright and Jordan, 2006), we show that these same algorithms can be used to solve an approximate sparse maximum likelihood problem for the binary case. We test our algorithms on synthetic data, as well as on gene expression and senate voting records data.

Feature selection techniques have become an apparent need in many bioinformatics applications. In addition to the large pool of techniques that have already been developed in the machine learning and data mining fields, specific applications in bioinformatics have led to a wealth of newly proposed techniques. In this paper, we make the interested reader aware of the possibilities of feature selection, providing a basic taxonomy of feature selection techniques, and discussing their use, variety and potential in a number of both common as well as upcoming bioinformatics applications. Companion website:

points. We introduce the bigraphical lasso, an estimator for precision matrices of matrix-normals based on the Cartesian product of graphs. A prominent product in spectral graph theory, this structure has appealing properties for regression, enhanced sparsity and interpretability. To deal