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3,982
Cytokine Secretion by Cystic Fibrosis Airway
"... It is controversial whether mutations in cystic fibrosis transmembrane conductance regulator intrinsically dysregulate inflammation. We characterized passage 2 human tracheobronchial epithelial cell cultures morphologically and physiologically and determined whether cytokine production or nuclear fa ..."
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-CF and CF cells. The cytokines regulated upon activation, normal T cell expressed and secreted (RANTES) and IL-10 were not detectable.
Cytokine secretion by immune cells in space
"... Abstract: Cultured, bone marrow-derived macrophages, murine spleen and lymph node cells, and human lymphocytes were tested for their ability to secrete cytokines in space. Lipopolysaccharide-activated bone marrow macrophages were found to secrete significantly more interleukin-1 and tumor necrosis f ..."
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Abstract: Cultured, bone marrow-derived macrophages, murine spleen and lymph node cells, and human lymphocytes were tested for their ability to secrete cytokines in space. Lipopolysaccharide-activated bone marrow macrophages were found to secrete significantly more interleukin-1 and tumor necrosis
JCB: ARTICLE Cytokine secretion requires phosphatidylcholine synthesis
"... Choline cytidylyltransferase (CCT) is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway. Here, we demonstrate that CCT �-mediated phosphatidylcholine synthesis is required to maintain normal Golgi structure and function as well as cytokine secretion from the Golgi complex. CCT ..."
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Choline cytidylyltransferase (CCT) is the rate-limiting enzyme in the phosphatidylcholine biosynthetic pathway. Here, we demonstrate that CCT �-mediated phosphatidylcholine synthesis is required to maintain normal Golgi structure and function as well as cytokine secretion from the Golgi complex
REVIEW P1 receptors and cytokine secretion
"... Abstract Evidence has accumulated in the last three decades to suggest tissue protection and regeneration by adenosine in multiple different cell types. Adenosine produced in hypoxic or inflamed environments reduces tissue injury and promotes repair by receptor-mediated mechanisms. Among other actio ..."
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Cited by 2 (0 self)
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actions, regulation of cytokine production and secretion by immune cells, astrocytes and microglia (the brain immunocytes) has emerged as a main mechanism at the basis of adenosine effects in diseases characterized by a marked inflammatory component. Many recent studies have highlighted that signalling
Galectin-9 Enhances Cytokine Secretion, but Suppresses
, 2013
"... Galectin-9 (Gal-9), a lectin having a b-galactoside-binding domain, can induce apoptosis of Th1 cells by binding to TIM-3. In addition, Gal-9 inhibits IgE/Ag-mediated degranulation of mast cell/basophilic cell lines by binding to IgE, thus blocking IgE/ Ag complex formation. However, the role of Gal ..."
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/ionomycin-mediated degranulation of HMC-1 cells. On the other hand, Gal-9 induced cytokine and/or chemokine production by HMC-1 cells, dependent on activation of ERK1/2 but not p38 MAPK. In addition, the lectin activity of Gal-9 was required for Gal-9-mediated cytokine secretion by HMC-1 cells. These observations suggest that Gal
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
- Nat. Cell Biol. 2009
"... Cellular senescence suppresses cancer by stably arresting the proliferation of damaged cells1. Paradoxically, senescent cells also secrete factors that alter tissue microenvironments2. The pathways regulating this secretion are unknown. We show that damaged human cells develop persistent chromatin l ..."
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Cited by 43 (1 self)
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lesions bearing hallmarks of DNA double-strand breaks (DSBs), which initiate increased secretion of inflammatory cytokines such as interleukin-6 (IL-6). Cytokine secretion occurred only after establishment of persistent DNA damage signaling, usually associated with senescence, not after transient DNA
Pycnogenol Augments Macrophage Phagocytosis and Cytokine Secretion
"... Abstract: We previously reported that Pycnogenol, procyanidins extracted from the bark of French maritime pine (Pinus maritima Aiton; the official botanical name is now Pinus pinaster Aiton) is a potent free radical scavenger. It has been shown to inhibit macrophage oxidative burst. Macrophages carr ..."
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that Pycnogenol can enhance the macrophage function by increasing its ability to phagocytosis and secretion of TNF- " and IL-1$. These two cytokines may provide costimulatory signals to enhance both the humoral and cellular immune responses to promote host defense. Key Words: Pycnogenol, J774 murine
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