cautioned not to depend on the values which appear in examples to be current or complete, since their purpose is

ation, and termination phases of protein synthesis. Because the structures of several DNA and RNA polymerases have been determined at atomic resolution, the mechanisms of DNA and RNA synthesis are both well understood. Determination of the structure of the ribosome, however, has proven a daunting task. It is several times larger than the largest polymerase, and 100 times larger than lysozyme, the first enzyme to be understood at atomic resolution. Until now an atomic resolution structure for the ribosome has not been available, and as a result the mechanism of protein synthesis has remained a mystery. Electron microscopy has contributed to our understanding of ribosome structure ever since the ribosome was discovered. In the last few years, three-dimensional (3D) electron microscopic images of the ribosome have been produced at resolutions sufficiently high to visualize many of the proteins and nucleic acids that assist in protein synthesis bound to the ribosome (3). Earlier this yea

in an organisation, relationships to define interactions between roles and management structures to define a configuration of roles and relationships pertaining to an organisational unit such as a department. These reusable composite policy specifications cater for the complexity of large enterprise information

This document is a revision of the public working draft dated 1998-08-19 incorporating suggestions received in review comments and further deliberations of the W3C RDF Model and Syntax Working Group. With the publication of this draft, the RDF Model and Syntax Specification enters "last call

To support the sharing and reuse of formally represented knowledge among AI systems, it is useful to define the common vocabulary in which shared knowledge is represented. A specification of a representational vocabulary for a shared domain of discourse — definitions of classes, relations

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We give an efficient procedure for verifying that a finite-state concurrent system meets a specification expressed in a (propositional, branching-time) temporal logic. Our algorithm has complexity linear in both the size of the specification and the size of the global state graph for the concurrent

The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine� threonine-specific protein kinases have been examined against a large panel of protein kinases. The compounds KT 5720, Rottlerin and quercetin were found to inhibit many

Note: This document consists of an approximate rendering in ASCII of the PostScript document of the same name. It is provided for convenience and for use in searches, etc. However, most tables, figures, equations and captions have not been rendered and the pagination and section headings are not available. This document describes the Network Time Protocol (NTP), specifies its formal structure and summarizes information useful for its implementation. NTP provides the mechanisms to synchronize time and coordinate time distribution in a large, diverse internet operating at rates from mundane to lightwave. It uses a returnable-time design in which a distributed subnet of time servers operating in a selforganizing, hierarchical-master-slave configuration synchronizes local clocks within the subnet and to national time standards via wire or radio. The servers can also redistribute reference time via local routing algorithms and time daemons. Status of this Memo This RFC specifies an IAB standards track protocol for the Internet community and requests discussion and suggestions for improvements. Please refer to the current edition of the <169>IAB Official Protocol Standards<170> for the standardization state and status of this protocol. Distribution of this memo is unlimited.

The rapid growth of the World-Wide Web poses unprecedented scaling challenges for general-purpose crawlers and search engines. In this paper we describe a new hypertext resource discovery system called a Focused Crawler. The goal of a focused crawler is to selectively seek out pages that are relevant to a pre-defined set of topics. The topics are specified not using keywords, but using exemplary documents. Rather than collecting and indexing all accessible Web documents to be able to answer all possible ad-hoc queries, a focused crawler analyzes its crawl boundary to find the links that are likely to be most relevant for the crawl, and avoids irrelevant regions of the Web. This leads to significant savings in hardware and network resources, and helps keep the crawl more up-to-date. To achieve such goal-directed crawling, we designed two hypertext mining programs that guide our crawler: a classifier that evaluates the relevance of a hypertext document with respect to the focus topics, ...