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The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
- Science
, 2000
"... ation, and termination phases of protein synthesis. Because the structures of several DNA and RNA polymerases have been determined at atomic resolution, the mechanisms of DNA and RNA synthesis are both well understood. Determination of the structure of the ribosome, however, has proven a daunting t ..."
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Cited by 529 (13 self)
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ation, and termination phases of protein synthesis. Because the structures of several DNA and RNA polymerases have been determined at atomic resolution, the mechanisms of DNA and RNA synthesis are both well understood. Determination of the structure of the ribosome, however, has proven a daunting task. It is several times larger than the largest polymerase, and 100 times larger than lysozyme, the first enzyme to be understood at atomic resolution. Until now an atomic resolution structure for the ribosome has not been available, and as a result the mechanism of protein synthesis has remained a mystery. Electron microscopy has contributed to our understanding of ribosome structure ever since the ribosome was discovered. In the last few years, three-dimensional (3D) electron microscopic images of the ribosome have been produced at resolutions sufficiently high to visualize many of the proteins and nucleic acids that assist in protein synthesis bound to the ribosome (3). Earlier this yea
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res
, 1983
"... We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters. Conditions of extraction and assay have been optimized for maximum activity using the major late promoter of adenovirus 2. T ..."
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Cited by 1054 (11 self)
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We have developed a procedure for preparing extracts from nuclei of human tissue culture cells that directs accurate transcription initiation in vitro from class II promoters. Conditions of extraction and assay have been optimized for maximum activity using the major late promoter of adenovirus 2. The extract also directs accurate transcription initiation from other adeno-virus promoters and cellular promoters. The extract also directs accurate transcription initiation from class III promoters (tRNA and Ad 2 VA).
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
, 1989
"... you have obtained prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your personal, non-commercial use. Please contact the publisher regarding any further use of this work. Publisher contact inform ..."
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Cited by 635 (14 self)
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you have obtained prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your personal, non-commercial use. Please contact the publisher regarding any further use of this work. Publisher contact information may be obtained at
A combined corner and edge detector
- In Proc. of Fourth Alvey Vision Conference
, 1988
"... Consistency of image edge filtering is of prime importance for 3D interpretation of image sequences using feature tracking algorithms. To cater for image regions containing texture and isolated features, a combined corner and edge detector based on the local auto-correlation function is utilised, an ..."
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Cited by 2430 (2 self)
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Consistency of image edge filtering is of prime importance for 3D interpretation of image sequences using feature tracking algorithms. To cater for image regions containing texture and isolated features, a combined corner and edge detector based on the local auto-correlation function is utilised
Ontologies: Silver Bullet for Knowledge Management and Electronic Commerce
, 2007
"... Currently computers are changing from single isolated devices to entry points into a world wide network of information exchange and business transactions called the World Wide Web (WWW). Therefore support in the exchange of data, information, and knowledge exchange is becoming the key issue in cur ..."
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Cited by 643 (46 self)
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Currently computers are changing from single isolated devices to entry points into a world wide network of information exchange and business transactions called the World Wide Web (WWW). Therefore support in the exchange of data, information, and knowledge exchange is becoming the key issue
Nonmonotonic Reasoning, Preferential Models and Cumulative Logics
, 1990
"... Many systems that exhibit nonmonotonic behavior have been described and studied already in the literature. The general notion of nonmonotonic reasoning, though, has almost always been described only negatively, by the property it does not enjoy, i.e. monotonicity. We study here general patterns of ..."
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Cited by 624 (14 self)
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of nonmonotonic reasoning and try to isolate properties that could help us map the field of nonmonotonic reasoning by reference to positive properties. We concentrate on a number of families of nonmonotonic consequence relations, defined in the style of Gentzen [13]. Both proof-theoretic and semantic points
A Meta-Analytic Review of Experiments Examining the Effects of Extrinsic Rewards on Intrinsic Motivation
"... A meta-analysis of 128 studies examined the effects of extrinsic rewards on intrinsic motivation. As predicted, engagement-contingent, completion-contingent, and performance-contingent rewards signifi-cantly undermined free-choice intrinsic motivation (d =-0.40,-0.36, and-0.28, respectively), as did ..."
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Cited by 602 (16 self)
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A meta-analysis of 128 studies examined the effects of extrinsic rewards on intrinsic motivation. As predicted, engagement-contingent, completion-contingent, and performance-contingent rewards signifi-cantly undermined free-choice intrinsic motivation (d =-0.40,-0.36, and-0.28, respectively
LOF: Identifying Density-Based Local Outliers
- PROCEEDINGS OF THE 2000 ACM SIGMOD INTERNATIONAL CONFERENCE ON MANAGEMENT OF DATA
, 2000
"... For many KDD applications, such as detecting criminal activities in E-commerce, finding the rare instances or the outliers, can be more interesting than finding the common patterns. Existing work in outlier detection regards being an outlier as a binary property. In this paper, we contend that for m ..."
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Cited by 499 (14 self)
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that for many scenarios, it is more meaningful to assign to each object a degree of being an outlier. This degree is called the local outlier factor (LOF) of an object. It is local in that the degree depends on how isolated the object is with respect to the surrounding neighborhood. We give a detailed formal
Halfa century of research on the Stroop effect: An integrative review
- PsychologicalBulletin
, 1991
"... The literature on interference in the Stroop Color-Word Task, covering over 50 years and some 400 studies, is organized and reviewed. In so doing, a set ofl 8 reliable empirical findings is isolated that must be captured by any successful theory of the Stroop effect. Existing theoretical positions a ..."
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Cited by 621 (14 self)
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The literature on interference in the Stroop Color-Word Task, covering over 50 years and some 400 studies, is organized and reviewed. In so doing, a set ofl 8 reliable empirical findings is isolated that must be captured by any successful theory of the Stroop effect. Existing theoretical positions
Illusion and well-being: A social psychological perspective on mental health
- Psychological Bulletin
, 1988
"... Many prominent theorists have argued that accurate perceptions of the self, the world, and the future are essential for mental health. Yet considerable research evidence suggests that overly positive selfevaluations, exaggerated perceptions of control or mastery, and unrealistic optimism are charact ..."
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Cited by 923 (20 self)
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both the social world and cognitive-processing mechanisms impose filters on incoming information that distort it in a positive direction; negative information may be isolated and represented in as unthreatening a manner as possible. These positive illusions may be especially useful when an individual
Results 1 - 10
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1,401,560