The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine� threonine-specific protein kinases have been examined against a large panel of protein kinases. The compounds KT 5720, Rottlerin and quercetin were found to inhibit many protein kinases, sometimes much more potently than their presumed targets, and conclusions drawn from their use in cell-based experiments are likely to be erroneous. Ro 318220 and related bisindoylmaleimides, as well as H89, HA1077 and Y 27632, were more selective inhibitors, but still inhibited two or more protein kinases with similar potency. LY 294002 was found to inhibit casein kinase-2 with similar potency to phosphoinositide (phosphatidylinositol) 3-kinase. The compounds with the most

Memory, reasoning, and categorization: parallels and

Common mechanisms for the representation of real, implied, and imagined visual motion by

), and is controlled by the subject. A series of studies using both reaction time and accuracy measures is presented, which traces these concepts in the form of automatic detection and controlled, search through the areas of detection, search, and attention. Results in these areas are shown to arise from common

Awareness of individual and group activities is critical to successful collaboration and is commonly supported in CSCW systems by active, information generation mecha-nisms separate from the shared workspace. These mechanisms pena~ise information providers, presuppose rel-evance to the recipient

representation in Static Single Assignment (SSA) form, with several novel features: a simple, language-independent type-system that exposes the primitives commonly used to implement high-level language features; an instruction for typed address arithmetic; and a simple mechanism that can be used to implement

Evolutionary computation is becoming common in the solution of difficult, realworld problems in industry, medicine, and defense. This paper reviews some of the practical advantages to using evolutionary algorithms as compared with classic methods of optimization or artificial intelligence. Specific

A method for anomaly detection is introduced in which "normal" is defined by short-range correlations in a process ' system calls. Initial experiments suggest that the definition is stable during normal behavior for standard UNIX programs. Further, it is able to detect several common

The Ponder language provides a common means of specifying security policies that map onto various access control implementation mechanisms for firewalls, operating systems, databases and Java. It supports obligation policies that are event triggered conditionaction rules for policy based management

Abstract A distributed system can be characterized by the fact that the global state is distributed and that a common time base does not exist. However, the notion of time is an important concept in every day life of our decentralized \ r eal world" and helps to solve problems like getting a