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Chronic Restraint Stress Upregulates Erythropoiesis through Glucocorticoid Stimulation

by Jeffrey L. Voorhees, Nicole D. Powell, Leni Moldovan, Xiaokui Mo, Timothy D. Eubank, Clay B , 2013
"... In response to elevated glucocorticoid levels, erythroid progenitors rapidly expand to produce large numbers of young erythrocytes. Previous work demonstrates hematopoietic changes in rodents exposed to various physical and psychological stressors, however, the effects of chronic psychological stres ..."
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stress on erythropoiesis has not be delineated. We employed laboratory, clinical and genomic analyses of a murine model of chronic restraint stress (RST) to examine the influence of psychological stress on erythropoiesis. Mice exposed to RST demonstrated markers of early erythroid expansion involving

Effect of Chronic Restraint Stress on Human Colorectal Carcinoma Growth in Mice

by Qiang Lin, Feifei Wang, Rong Yang, Xinmin Zheng, Huibao Gao, Ping Zhang , 2013
"... Stress alters immunological and neuroendocrinological functions. An increasing number of studies indicate that chronic stress can accelerate tumor growth, but its role in colorectal carcinoma (CRC) progression is not well understood. The aim of this study is to investigate the effects of chronic res ..."
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Stress alters immunological and neuroendocrinological functions. An increasing number of studies indicate that chronic stress can accelerate tumor growth, but its role in colorectal carcinoma (CRC) progression is not well understood. The aim of this study is to investigate the effects of chronic

The Effects of Oxytocin on Cognitive Defect Caused by Chronic Restraint Stress Applied to Adolescent Rats and on Hippocampal VEGF and BDNF Levels

by Abcdef Ayfer Dayi, B Ferihan Cetin, Bc Ali, Riza Sisman, B Ilkay Aksu, B Aysegul Tas, D Sevil Gönenc, Abcdef Nazan Uysal
"... Source of support: Departmental sources Background: Because brain development continues during adolescence, the effects of chronic stress on hippocampal chang-es that occur during that period are permanent. Oxytocin, which is synthesized in the hypothalamus and has many receptors in brain regions, i ..."
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, including the hippocampus, may affect learning-memory. This study aimed to investigate chronic restraint stress on hippocampal functions, and hippocampal vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) levels in adolescent male and female rats and the role of oxytocin

‘‘Green Odor’ ’ Inhalation Reduces the Skin-Barrier Disruption Induced by Chronic Restraint Stress in Rats: Physiological and Histological Examinations

by Mika Fukada, Toshiyuki Kaidoh, Ai Ito, Tomomi Yano, Chie Hayashibara, Tatsuo Watanabe
"... We investigated whether inhalation of green odor (a mixture of equal amounts of trans-2-hexenal and cis-3-hexenol) prevents the skin-barrier disruption induced by chronic restraint stress in rats. To this end, transepidermal water loss (TEWL) was measured as an index of the disruption of skin-barrie ..."
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We investigated whether inhalation of green odor (a mixture of equal amounts of trans-2-hexenal and cis-3-hexenol) prevents the skin-barrier disruption induced by chronic restraint stress in rats. To this end, transepidermal water loss (TEWL) was measured as an index of the disruption of skin

Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress

by L. A. M. Galea, B. S. Mcewen, P. Tanapat, T. Deak, R. L. Spencer, F. S. Dhabhar - Neuroscience , 1997
"... Abstract––The present study investigated the effects of 21 days of chronic restraint stress on neural and endocrine parameters in male and female rats. Consistent with previous results, repeated restraint stress induced apical dendritic atrophy (a decrease in the number of apical branch points and d ..."
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Abstract––The present study investigated the effects of 21 days of chronic restraint stress on neural and endocrine parameters in male and female rats. Consistent with previous results, repeated restraint stress induced apical dendritic atrophy (a decrease in the number of apical branch points

Research Article The Alterations of IL-1Beta, IL-6, and TGF-Beta Levels in Hippocampal CA3 Region of Chronic Restraint Stress Rats after

by Electroacupuncture (ea Pretreatment, A. Yingge, Xiaotian He, Tu Ya
"... which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Immunological reactions induced by proinflammatory cytokines have been involved in the pathogenesis of depressive disorders. Recent studies showed that Electroacupuncture (EA) ..."
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) was able to reduce depressive symptoms; however, the underlyingmechanism and its potential targets remain unknown. In the present study, we used a 21-day chronic restraint stress rats as a model to investigate how EA could alleviate depression. Open field test was carried out to evaluate the depressive

The Role of Peripheral Cannabinoid Receptors Type 1 in Rats With Visceral Hypersensitivity Induced by Chronic Restraint Stress

by J Neurogastroenterol Motil
"... This study was designed to investigate the possibility that the enhanced nociceptive responsiveness associated with canabonoid type 1 receptors (CB1Rs) and identify its role in mediating visceral hypersensitivity induced by chronic restraint stress. Methods Rats were exposed to daily partial restrai ..."
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This study was designed to investigate the possibility that the enhanced nociceptive responsiveness associated with canabonoid type 1 receptors (CB1Rs) and identify its role in mediating visceral hypersensitivity induced by chronic restraint stress. Methods Rats were exposed to daily partial

Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

by Koji Murao, Jing-wei Chen, Wen-qing Fu, Guo-xing Zhang
"... Backgrounds: Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP) mediated immune response, the role of reactive oxygen species (ROS) in brain-skin-axis regulation system remains unknown. Objectives: The present study aims ..."
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aims to investigate possible mechanisms of ROS in regulation of SP-mast cell signal pathway in chronic restraint stress (CRS, a model of chronic psychoemotional stress) which induced abnormal of hair cycle. Methods and Results: Our results have demonstrated that CRS actually altered hair cycle

Influence of omega-3 fatty acid status on the way rats adapt to chronic restraint stress. PLoS One 7: e42142

by Marie Hennebelle, Laure Balasse, Gaelle Champeil-potokar , 2012
"... Omega-3 fatty acids are important for several neuronal and cognitive functions. Altered omega-3 fatty acid status has been implicated in reduced resistance to stress and mood disorders. We therefore evaluated the effects of repeated restraint stress (6 h/day for 21 days) on adult rats fed omega-3 de ..."
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the amounts of omega-3 incorporated. These data showed that the response to chronic restraint stress was modulated by the omega-3 fatty acid supply, a dietary deficiency

Original Article Effects of Chronic Restraint Stress on Body Weight, Food Intake, and Hypothalamic Gene

by Endocrinol Metab, Expressions In Mice, Joo Yeon Jeong, Dong Hoon Lee, Sang Soo Kang
"... Background: Stress affects body weight and food intake, but the underlying mechanisms are not well understood. Methods: We evaluated the changes in body weight and food intake of ICR male mice subjected to daily 2 hours restraint stress for 15 days. Hypothalamic gene expression profiling was analyze ..."
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recovered to 90 % of the control intake at the end of the experiment. cDNA microarray analysis revealed that chron-ic restraint stress affects the expression of hypothalamic genes possibly related to body weight control. Since decreases of daily food intake and body weight were remarkable in days 1 to 4
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