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The structure of the potassium channel: molecular basis of K+ conduction and selectivity

by Declan A. Doyle, João Morais Cabral, Richard A. Pfuetzner, Anling Kuo, Jacqueline M. Gulbis, Steven L. Cohen, Brian T. Chait, Roderick Mackinnon - Science , 1998
"... The potassium channel from Streptomyces lividans is an integral membrane protein with sequence similarity to all known K1 channels, particularly in the pore region. X-ray analysis with data to 3.2 angstroms reveals that four identical subunits create an inverted teepee, or cone, cradling the selecti ..."
Abstract - Cited by 460 (1 self) - Add to MetaCart
in the pore at the center of the bilayer. Main chain carbonyl oxygen atoms from the K1 channel signature sequence line the selectivity filter, which is held open by structural constraints to co-ordinate K1 ions but not smaller Na1 ions. The selectivity filter contains two K1 ions about 7.5 angstroms apart

Ricci Flow with Surgery on Three-Manifolds

by Grisha Perelman
"... This is a technical paper, which is a continuation of [I]. Here we verify most of the assertions, made in [I, §13]; the exceptions are (1) the statement that a 3-manifold which collapses with local lower bound for sectional curvature is a graph manifold- this is deferred to a separate paper, as the ..."
Abstract - Cited by 448 (2 self) - Add to MetaCart
was considered by Hamilton [H 5,§4,5]; unfortunately, his argument, as written, contains an unjustified statement (RMAX = Γ, on page 62, lines 7-10 from the bottom), which I was unable to fix. Our approach is somewhat different, and is aimed at eventually constructing a canonical Ricci flow, defined on a largest

Evaluation of Center-Line Extraction Algorithms in

by Quantitative Coronary Angiography, H. Greenspan, M. Laifenfeld, S. Einav, O. Barnea, Senior Member - IEEE Trans. Med. Imag , 2001
"... Objective testing of centerline extraction accuracy in quantitative coronary angiography (QCA) algorithms is a very difficult task. Standard tools for this task are not yet available. We present a simulation tool that generates synthetic angiographic images of a single coronary artery with predeterm ..."
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Objective testing of centerline extraction accuracy in quantitative coronary angiography (QCA) algorithms is a very difficult task. Standard tools for this task are not yet available. We present a simulation tool that generates synthetic angiographic images of a single coronary artery with predetermined centerline and diameter function. This simulation tool was used creating a library of images for the objective comparison and evaluation of QCA algorithms. This technique also provides the means for understanding the relationship between the algorithms' performance and limitations and the vessel's geometrical parameters. In this paper, two algorithms are evaluated and the results are presented. Index Terms---Centerline estimation, coronary geometrical complexity, lumen centerline detection, performance evaluation, QCA, simulation tool.

RELATION BETWEEN PORE MODEL AND CENTER-LINE TEMPERATURE

by In High, Burn-up Uo Pellet , 2007
"... Relation between pore model and center-line temperature of high burn up UO2 Pellet. Temperature distribution has been evaluated by using different model of pore distribution. Typical data of power distribution and coolant data have been chosen in this study. Different core model and core distributio ..."
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Relation between pore model and center-line temperature of high burn up UO2 Pellet. Temperature distribution has been evaluated by using different model of pore distribution. Typical data of power distribution and coolant data have been chosen in this study. Different core model and core

Authenticated Key Exchange Secure Against Dictionary Attacks

by Mihir Bellare, David Pointcheval, Phillip Rogaway , 2000
"... Password-based protocols for authenticated key exchange (AKE) are designed to work despite the use of passwords drawn from a space so small that an adversary might well enumerate, off line, all possible passwords. While several such protocols have been suggested, the underlying theory has been laggi ..."
Abstract - Cited by 402 (35 self) - Add to MetaCart
Password-based protocols for authenticated key exchange (AKE) are designed to work despite the use of passwords drawn from a space so small that an adversary might well enumerate, off line, all possible passwords. While several such protocols have been suggested, the underlying theory has been

AN ALGORITHM FOR GENERATING ROAD CENTER-LINES FROM ROAD RIGHTS-OF-WAY

by Naven E. Olson
"... A totally vector geometric algorithm was developed for generating road center-lines from road rights-of-way The algorithm finds pairs of parallel arc sections within a given distance. The user passes the name of the right-of-way layer, the name of the new center-line layer, a road width, and an expa ..."
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A totally vector geometric algorithm was developed for generating road center-lines from road rights-of-way The algorithm finds pairs of parallel arc sections within a given distance. The user passes the name of the right-of-way layer, the name of the new center-line layer, a road width

along the center lines of ocular dominance bands (Bart-

by Michael C. Crair, Edward S. Ruthazer, Deda C. Gillespie, Michael P. Stryker
"... one eye or the other tend to lie on or near the singularities ..."
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one eye or the other tend to lie on or near the singularities

Center Line Coordinates Survey for Existing Railway by 3-D Constraints Method

by unknown authors , 2013
"... Since the maintenance of HSR depends both on inner geometries and outer geometries information of track, it’s necessary that the survey technologies could measure the smoothness and coordinates of track in a high-density manner. But the existing technologies for track survey are either inaccurate or ..."
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is obtaining center line locus with location information by means of survey trolley and CP- stakes. By measuring the distances between trolley and CP- stakes, the boundary condition could be determined. So, the problem of center line calculation is transformed into the problem of definite integral for FOG

Cities and the creative class.

by Richard Florida , Richard Florida , H John Heinz - City and Community, , 2003
"... Cities and regions have long captured the imagination of sociologists, economists, and urbanists. From Alfred Marshall to Robert Park and Jane Jacobs, cities have been seen as cauldrons of diversity and difference and as fonts for creativity and innovation. Yet until recently, social scientists con ..."
Abstract - Cited by 359 (1 self) - Add to MetaCart
cities and communities, and does so particularly in light of themes advanced in my recently published book, The Rise of the Creative Class, which focuses on diversity and creativity as basic drivers of innovation and regional and national growth. This line of work further suggests the need for some

Efficient center-line extraction for quantification of vessels in confocal microscopy images

by Mahnaz Maddah, B Ali Afzali-kusha, A Hamid Soltanian-zadeh A - Med. Phys , 2003
"... In this paper we present a novel method for the 3D centerline extraction of elongated objects such as vessels. This method unites the basic ideas in distance transformbased, thinning, and path planning methods to extract thin and connected centerlines. This fast approach needs no user interaction or ..."
Abstract - Cited by 4 (0 self) - Add to MetaCart
In this paper we present a novel method for the 3D centerline extraction of elongated objects such as vessels. This method unites the basic ideas in distance transformbased, thinning, and path planning methods to extract thin and connected centerlines. This fast approach needs no user interaction or any prior knowledge of the object shape. Centerline extraction is the first and most important step towards the quantification of vascular images which is beneficial for research, diagnosis, surgery planning, and therapy. The results confirm the superiority of our proposed method when applied to the complex branching structures of vessels in the confocal microscopy images of a rat brain. 1.
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