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CD163 Expression Was Associated with Angiogenesis and Shortened Survival in Patients with Uniformly Treated Classical Hodgkin Lymphoma

by Young Wha Koh, Chan-sik Park, Dok Hyun Yoon, Cheolwon Suh, Jooryung Huh , 2014
"... Background: Recent studies have reported the prognostic value of tissue-associated magrophages (TAMs) in classical Hodgkin lymphoma (cHL). In addition, TAMs are implicated in the tumor angiogenesis. In this study, we examined the prognostic relevance of TAMs in relation to vascular endothelial growt ..."
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growth factor (VEGF) expression and angiogenesis in uniformly treated cases of cHL. Methods: Diagnostic tissue from 116 patients with ABVD-treated cHL was evaluated retrospectively by immunohisto-chemical analysis for CD68, CD163 and VEGF expression and for CD31 expression as a measure of microvessel

Lesional Accumulation of CD163-Expressing Cells in the Gut of Patients with Inflammatory Bowel Disease

by Roberta Caruso, Carmine Stolfi, Massimiliano Sarra, Maria Laura Cupi, Flavio Caprioli, Ivan Monteleone, Francesca Zorzi, Daniela De Nitto, Alfredo Colantoni, Livia Biancone, Francesco Pallone, Giovanni Monteleone
"... Monocytes/macrophages displaying different markers of activation/differentiation infiltrate the inflamed gut of patients with inflammatory bowel diseases (IBD), but the role that each monocyte/macrophage subpopulation plays in the pathogenesis of IBD is not fully understood. The hemoglobin scavenger ..."
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scavenger receptor CD163, a specific marker of monocytes/ macrophages, has been associated with either anti-inflammatory or inflammatory functions of macrophages in several pathologies. In this study we examined the tissue distribution and function of CD163-expressing monocytes/macrophages in IBD. CD163 RNA

The Identification of CD163 Expressing Phagocytic Chondrocytes in Joint Cartilage and Its Novel Scavenger Role in Cartilage Degradation

by Kai Jiao, Jing Zhang, Mian Zhang, Yuying Wei, Yaoping Wu, Zhong Ying Qiu, Jianjun He, Yunxin Cao, Jintao Hu, Han Zhu, Li-na Niu, Xu Cao, Kun Yang, Mei-qing Wang
"... Background: Cartilage degradation is a typical characteristic of arthritis. This study examined whether there was a subset of phagocytic chondrocytes that expressed the specific macrophage marker, CD163, and investigated their role in cartilage degradation. Methods: Cartilage from the knee and tempo ..."
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Background: Cartilage degradation is a typical characteristic of arthritis. This study examined whether there was a subset of phagocytic chondrocytes that expressed the specific macrophage marker, CD163, and investigated their role in cartilage degradation. Methods: Cartilage from the knee

by pro- and

by Christa Buechler, Mirko Ritter, Evelyn Orsó, Thomas Langmann, Jochen Klucken, Gerd Schmitz
"... Regulation of scavenger receptor CD163 expression in human monocytes and macrophages ..."
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Regulation of scavenger receptor CD163 expression in human monocytes and macrophages

BRIEF COMMUNICATION

by Christian A. Schaer, Florence Vallelian, Er Imhof, Gabriele Schoedon, Dominik J. Schaer
"... CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system ..."
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CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system

CD163 and its role in inflammation

by Internal Medicine, Krzysztof Kowal, Richard Silver, Emila Sławińska, Marek Bielecki, Lech Chyczewski Otylia
"... Abstract: Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopula-tions exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential. The ..."
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Abstract: Mononuclear phagocytes represent a heterogeneous population of cells with individual subpopula-tions exerting different pro- or anti-inflammatory functions. CD163 is a monocyte/macrophage specific marker expressed predominantly on cells which possess strong anti-inflammatory potential

Differential Expression of CD163 on Monocyte Subsets in Healthy and HIV-1 Infected Individuals

by Wan-jung Cheng, Clare Westhorpe, Paul U. Cameron, Bruce J. Brew, Sharon R, Anthony Jaworowski, Suzanne M. Crowe
"... CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities in HIV-infected individuals, particularly dementia and cardiovascular disease, result in part from effects of HIV-1 infe ..."
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CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities in HIV-infected individuals, particularly dementia and cardiovascular disease, result in part from effects of HIV-1

RESEARCH Open Access Liver myofibroblasts up-regulate monocyte CD163

by Zhanlian Huang, Qiang Tai, Yutian Chong, Zhiliang Gao
"... Background: Although patients with liver failure exhibit a generalized inflammatory-imbalance status, substantial evidence indicates that this immunosuppressive or anti-inflammatory state may be deleterious. Increased expression of CD163 (known to be involved in several anti-inflammatory functions o ..."
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Background: Although patients with liver failure exhibit a generalized inflammatory-imbalance status, substantial evidence indicates that this immunosuppressive or anti-inflammatory state may be deleterious. Increased expression of CD163 (known to be involved in several anti-inflammatory functions

Functional expression of the CD163 scavenger receptor on acute myeloid leukemia cells of monocytic lineage

by Esther B. Bächli, Dominik J. Schaer, B. Walter, Gabriele Schoedon - J. Leukoc. Biol , 2006
"... Abstract: The hemoglobin–haptoglobin (Hb–Hp) scavenger receptor CD163 is a monocyte/macro-phage-restricted surface antigen, whose expression is strongly up-regulated by glucocorticoids. We have previously shown that CD163 is expressed by acute myeloid leukemia (AML) cells of monocytic lineage. Herei ..."
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Abstract: The hemoglobin–haptoglobin (Hb–Hp) scavenger receptor CD163 is a monocyte/macro-phage-restricted surface antigen, whose expression is strongly up-regulated by glucocorticoids. We have previously shown that CD163 is expressed by acute myeloid leukemia (AML) cells of monocytic lineage

TGF-� regulation of human macrophage scavenger receptor CD163 is Smad3-dependent

by Patricia A. Pioli, Katie E. Goonan, Kathleen Wardwell, Paul M. Guyre - J. Leukocyte Biol , 2004
"... Abstract: Tight regulation of the inflammatory re-sponse is essential for the maintenance of physiologic homeostasis. A potentially important mediator of this process is CD163, a macrophage-specific member of the scavenger receptor cysteine-rich family. CD163 surface expression is up-regulated by gl ..."
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Abstract: Tight regulation of the inflammatory re-sponse is essential for the maintenance of physiologic homeostasis. A potentially important mediator of this process is CD163, a macrophage-specific member of the scavenger receptor cysteine-rich family. CD163 surface expression is up
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