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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory and preparative actions. Endocrine Rev 21:55–89

by Robert M. Sapolsky, L. Michael Romero, Allan, U. Munck , 2000
"... The secretion of glucocorticoids (GCs) is a classic endocrine re-sponse to stress. Despite that, it remains controversial as to what purpose GCs serve at such times. One view, stretching back to the time of Hans Selye, posits that GCs help mediate the ongoing or pending stress response, either via b ..."
Abstract - Cited by 331 (8 self) - Add to MetaCart
basal levels of GCs permitting other facets of the stress response to emerge efficaciously, and/or by stress levels of GCs actively stimulating the stress response. In con-trast, a revisionist viewpoint posits that GCs suppress the stress response, preventing it from being pathologically overactivated

QUARTERLY Review Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76) �

by Sanjay Awasthi, Rajendra Sharma, Yusong Yang, Sharad S. Singhal, Joanna B, Shivendra V. Singh, Piotr Zimniak, Yogesh C. Awasthi
"... We have recently demonstrated that a previously known Ral-binding GTPase activating protein, RLIP76, can also catalyze ATP-dependent transport of various structurally unrelated xeno- and endobiotics irrespective of their net charge (Awasthi et al., 2000, Biochemistry, 39: 9327). RLIP76 is a non-ATP ..."
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-ATP binding cassette (ABC) protein but it has two ATP-binding sites and shows basal ATPase activity which is stimulated

Adaptive Critics and the Basal Ganglia

by Andrew G. Barto - In , 1995
"... One of the most active areas of research in artificial intelligence is the study of learning methods by which “embedded agents ” can improve performance while acting in complex dynamic environments. An agent, or decision maker, is embedded in an environment when it receives information from, and act ..."
Abstract - Cited by 134 (10 self) - Add to MetaCart
One of the most active areas of research in artificial intelligence is the study of learning methods by which “embedded agents ” can improve performance while acting in complex dynamic environments. An agent, or decision maker, is embedded in an environment when it receives information from

BIOCHEMICAL AND CYTOCHEMICAL EVIDENCE FOR ATPase ACTIVITY IN BASAL BODIES ISOLATED FROM OVIDUCT

by Richard G. W. Anderson
"... Biochemical and cytochemical techniques were used to determine whether oviduct basal bodies have ATPase activity. All studies were carried out on basal bodies isolated and purified from the chicken oviduct. These preparations contained structurally intact basal bodies with basal feet, rootlet, and a ..."
Abstract - Cited by 6 (0 self) - Add to MetaCart
Biochemical and cytochemical techniques were used to determine whether oviduct basal bodies have ATPase activity. All studies were carried out on basal bodies isolated and purified from the chicken oviduct. These preparations contained structurally intact basal bodies with basal feet, rootlet

Shedding Light on ATPase Activity, Interaction with Adenosine Nucleotides, Solution Structure and Domain Organization

by Human Mitochondrial Hsp (mortalin, Paulo R. Dores-silva, Ro R. S. Barbosa, Carlos H. I. Ramos, Júlio C. Borges
"... The human mitochondrial Hsp70, also called mortalin, is of considerable importance for mi-tochondria biogenesis and the correct functioning of the cell machinery. In the mitochondrial matrix, mortalin acts in the importing and folding process of nucleus-encoded proteins. The in vivo deregulation of ..."
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provides the first report of the production of folded and soluble recombinant mortalin when co-expressed with the human Hsp70-escort protein 1, but it is still likely prone to self-association. The monomeric fraction of mortalin presented a slightly elongated shape and basal ATPase activity that is higher

Interactions Between Frontal Cortex and Basal Ganglia in Working Memory: A Computational Model

by Michael J. Frank, Bryan Loughry, Randall C. O'Reilly , 2000
"... The frontal cortex and basal ganglia interact via a relatively well-understood and elaborate system of interconnections. In the context of motor function, these interconnections can be understood as disinhibiting or "releasing the brakes" on frontal motor action plans --- the basal ganglia ..."
Abstract - Cited by 152 (18 self) - Add to MetaCart
exhibits robust active maintenance, while the basal ganglia contribute a selective, dynamic gating function that enables frontal memory representations to be rapidly updated in a task-relevant manner. We apply the model to a novel version of the continuous performance task (CPT) that requires subroutine

ATPase activity of Escherichia coli Rep helicase is dramatically dependent on DNA ligation and protein oligomeric states

by Isaac Wong, Keith J. M. Moore, Keith P. Bjornson, John Hsieh, Timothy M. Lohman - Biochemistry , 1996
"... ABSTRACT: The Escherichia coli Rep helicase catalyzes the unwinding of duplex DNA using the energy derived from ATP binding and hydrolysis. Rep functions as a dimer but assembles to its active dimeric form only on binding DNA. Each protomer of a dimer contains a DNA binding site that can bind either ..."
Abstract - Cited by 11 (7 self) - Add to MetaCart
, 350-355]. The basal ATPase activity of Rep protein is stimulated by ss DNA binding and by protein dimerization. We have measured the steady-state ATPase activities of Rep bound to dT(pT)15 in each distinct ss DNA ligation state (PS, P2S, and P2S2) to compare with our previous measurements

Control of Cardiac Sarcolemmal Adenylate Cyclase and Sodium, Potassium-Activated Adenosinetriphosphatase Activities

by Michihiko Tada, Madeleine A. Kirchberger, Jo-anna M. Lorio, Arnold M. Katz
"... A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The ..."
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. The basal ATPase activity of 4-6 pi moles Pj/hour mg"1 protein, measured in 120 ml! NaCl or KC1, was approximately doubled in 100 mM NaCl plus 20 mM KC1. This increment, the Na, K-ATPase, was abolished by 10~5M ouabain, the K, for ouabain being approximately 3 x 10 " 7M. /-Epinephrine had

Cyanobacterial ClpC/HSP100 protein displays intrinsic chaperone activity

by Fredrik I. Andersson, Robert Blakytny, Janine Kirstein, Kürsad Turgay, Bernd Bukau, Axel Mogk, Adrian K. Clarke - J. Biol. Chem , 2006
"... HSP100 proteins are molecular chaperones that belong to the broader family of AAA � proteins (ATPases associated with a variety of cellular activities) known to promote protein unfolding, disassembly of protein complexes and translocation of proteins across membranes. The ClpC form of HSP100 is an e ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
-based overexpression system. Recombinant SyClpC showed basal ATPase activity, similar to that of other types of HSP100 protein in non-photosynthetic organisms but different to ClpC in Bacillus subtilis. SyClpC also displayed distinct intrinsic chaperone activity in vitro, first by preventing aggregation of unfolded

The Role of the N-D1 Linker of the N-Ethylmaleimide- Sensitive Factor in the SNARE Disassembly

by Cui-cui Liu, Shan Sun, Sen-fang Sui , 2013
"... N-ethylmaleimide-sensitive factor (NSF) is a member of the type II AAA+ (ATPase associated with various cellular activities) family. It plays a critical role in intracellular membrane trafficking by disassembling soluble NSF attachment protein receptor (SNARE) complexes. Each NSF protomer consists o ..."
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mutagenesis analyses of NSF N-D1 linker, dissecting its role in the SNARE disassembly, the SNARE/a-SNAP complex binding, the basal ATPase activity and the SNARE/a-SNAP stimulated ATPase activity. Our results show that the N-terminal region of the N-D1 linker associated mutants cause severe defect in SNARE
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