Antigen presentation to T and B lymphocytes by antigen-presenting cells plays a central role in the initiation and regulation of adaptive immune responses. Antigen-presenting Cells Antigen presentation is an essential step in the initiation of clonal immune responses against viral, parasitic

Une théorie qui n’est réfutable par aucun évènement qui se puisse concevoir est dépourvue de caractère scientifique. (Karl Popper, Conjectures et réfutations) 2 Remerciements Merci au professeur Laurence Zitvogel de m’avoir accueilli dans son équipe. Merci au Pr Eric Solary d’avoir accepté de présider mon jury. Merci également aux Dr Anne Caignard et Dr Marc Grégoire d’en avoir accepté d’en être les rapporteurs, et merci aux Dr Salem Chouaib et Dr Thierry Walzer d’avoir été examinateurs de mon jury.

Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal

Interferon- � and granulocyte-macrophage colony-stimulating factor differentiate peripheral blood monocytes into potent

Histone acetylation regulates the cell type specific CIITA promoters, MHC class II expression and

Human NKT cells promote monocyte differentiation into suppressive myeloid

antigen-presenting cells

In this study we investigated the effect of an in vitro infection with Mycobacterium tuberculosis on the ability of human monocytes to present the soluble antigen tetanus toxoid to T cells. We observed that tetanus toxoid-specific T-cell proliferation was markedly reduced when monocytes were

Human gd T cells are considered to play a vital role in protective immunity through cytokine secretion and cytotoxic activity. We report that cells ex-pressing the Vg2Vd2þ–T cell receptor (Vd2þ T cells) also display principal characteristics of professional antigen-presenting cells

One of the remaining enigmas of the dendritic cell (DC) network is the potential contribution of plasmacytoid DCs (pDCs) to antigen presentation. Although the antigen-presentation capacity of conventional DCs (cDCs) is clearly defined, pDCs are generally attributed as having little, if any, antigen-presentation