Results 1 - 10 of 21,269

Apoptosis: a Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics

by J. F. R. Kerr, A. H. Wyllie, A. R. Curriet - Br. J. Cancer , 1972
"... Summary.-The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently program ..."
Abstract - Cited by 641 (6 self) - Add to MetaCart
by lysosomal enzymes derived from the ingesting cells. Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development. It occurs spontaneously in untreated malignant neoplasms, and participates in at least some

Rethinking the emotional brain

by Joseph LeDoux , 2012
"... ts fe o th emotion is, and how it differs from other aspects of mind and behavior, in spite of discussion and debate that dates back to emotion, since animal research is essential for identifying cally use these ‘‘feeling words’ ’ as guideposts to explore the terrain of emotion. One set of such phen ..."
Abstract - Cited by 678 (3 self) - Add to MetaCart
of such phenomena includes responses that occur whenProgress in understanding emotional phenomena in the brains of laboratory animals has in fact helped elucidate emotional functions in the human brain, including pathological aspects of responses that occur when in danger or when in the presence of a potential mate

Functional discovery via a compendium of expression profiles.

by Timothy R Hughes , Matthew J Marton , Allan R Jones , Christopher J Roberts , Roland Stoughton , Christopher D Armour , Holly A Bennett , Ernest Coffey , Hongyue Dai , Ross-Macdonald , Yudong D He , Matthew J Kidd , Amy M King , Michael R Meyer , David Slade , Pek Y Lum , Sergey B Stepaniants , Daniel D Shoemaker , Julian Simon , Martin Bard - Cell, , 2000
"... provided that the cellular transcriptional response to frames encode proteins required for sterol metabodisruption of different steps in the same pathway is lism, cell wall function, mitochondrial respiration, or similar, and that there are sufficiently unique transcripprotein synthesis. We also sh ..."
Abstract - Cited by 547 (9 self) - Add to MetaCart
provided that the cellular transcriptional response to frames encode proteins required for sterol metabodisruption of different steps in the same pathway is lism, cell wall function, mitochondrial respiration, or similar, and that there are sufficiently unique transcripprotein synthesis. We also

Model-Based Analysis of Oligonucleotide Arrays: Model Validation, Design Issues and Standard Error Application

by Cheng Li, Wing Hung Wong , 2001
"... Background: A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based expression indexes (MBEI). MBEI has standard error attached to it as a measure of ..."
Abstract - Cited by 775 (28 self) - Add to MetaCart
Background: A model-based analysis of oligonucleotide expression arrays we developed previously uses a probe-sensitivity index to capture the response characteristic of a specific probe pair and calculates model-based expression indexes (MBEI). MBEI has standard error attached to it as a measure

The Computational Brain.

by P S Churchland , T J Sejnowski , Bruce Bridgeman , 1994
"... Keywords: reductionism, neural networks, distributed coding, Karl Pribram, computational neuroscience, receptive field 1.1 The broad goal of this book, expressed at the start, is ``to understand how neurons give rise to a mental life.'' A mental reductionism is assumed in this seductively ..."
Abstract - Cited by 450 (7 self) - Add to MetaCart
, to interpret its activity as detecting a perceptual situation or driving a motor response. This approach, seemingly inescapable in the 1960s, became untenable, but there were no concrete alternatives. Evoked potential techniques gave only a gross average of activity, too vague to pin down mechanisms, and early

Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments

by Sandrine Dudoit, Yee Hwa Yang, Matthew J. Callow, Terence P. Speed - STATISTICA SINICA , 2002
"... DNA microarrays are a new and promising biotechnology whichallows the monitoring of expression levels in cells for thousands of genes simultaneously. The present paper describes statistical methods for the identification of differentially expressed genes in replicated cDNA microarray experiments. A ..."
Abstract - Cited by 438 (12 self) - Add to MetaCart
. Although it is not the main focus of the paper, new methods for the important pre-processing steps of image analysis and normalization are proposed. Given suitably normalized data, the biological question of differential expression is restated as a problem in multiple hypothesis testing: the simultaneous

characterization of biological responses in vitro

by Jenny Wegert, Sabrina Bausenwein, Susanne Kneitz, Sabine Roth, Norbert Graf, Eva Geissinger, Manfred Gessler
"... Retinoic acid pathway activity in wilms tumors and characterization of biological responses in vitro Wegert et al. Wegert et al. Molecular Cancer 2011, 10:136 ..."
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Retinoic acid pathway activity in wilms tumors and characterization of biological responses in vitro Wegert et al. Wegert et al. Molecular Cancer 2011, 10:136

Biological responses to electromagnetic fields

by Adam Lacy-hulbert, James C. Metcalfe, Robin Hesketh - FASEB Journal , 1998
"... ABSTRACT Electrification in developed countries has progressively increased the mean level of extremely low-frequency electromagnetic fields (ELF-EMFs) to which populations are exposed; these humanmade fields are substantially above the naturally occurring ambient electric and magnetic fields of Ç10 ..."
Abstract - Cited by 29 (0 self) - Add to MetaCart
notably on the activity of components of the pathways that regulate cell proliferation. However, the limited number of attempts to directly replicate these experimental findings have been almost uniformly unsuccessful, and no EMF-induced biological response has yet been replicated in independent

Antibiotics as biological response modifiers

by R. E. Ritts - Chemotherapy (Basel , 1990
"... This review suggests that infections are potent immunomodulators by causing significant alterations in one or more mediators of homeostasis and that an effective antibiosis may be a potent immunomodulator, albeit indirectly. When large numbers of microorganisms are killed, their enzymes and toxins a ..."
Abstract - Cited by 9 (0 self) - Add to MetaCart
are rapidly released and activate the immune system. The septic syndrome and the potentially progressive states of septic shock, acute respiratory distress syndrome and multiple organ system failure illustrate the biological response modulating (BRM) activity of both infection and antibiotic. Enhancement

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

by Norma Masson, Peter J. Ratcliffe - J Cell Sci
"... biological response to intracellular O2 levels ..."
Abstract - Cited by 22 (0 self) - Add to MetaCart
biological response to intracellular O2 levels
Results 1 - 10 of 21,269