The effects of chronic elevation of plasma epinephrine concen-trations on pressor and cardiac chronotropic responses to spinal stimulation and exogenous norepinephnne were studied in the pithed rat. Animals were treated s.c. with epinephrine (1 00 g/ kg/hr) or vehicle for 6 days. Treatment with epinephnne resulted in hypertension. Epinephnne treatment significantly reduced pressor and cardiac chronotropic responses to norepinephnne. This treatment also reduced cardiac chronotropic responses to spinal stimulation but had no significant effect on pressor re-sponses to spinal stimulation. The preferential beta-2 adreno-captor antagonist ICI 1 18,551 (50,g/kg) had no effect on pressor or cardiac chronotropic responses to norepinephnne in either vehicle-treated or epinephnne-treated animals. Similarly, pressor responses to spinal stimulation were unaffected in the

spinal cord transection increases susceptibility to reperfusion-induced

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Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications

within-breath modulation of muscle sympathetic nerve activity (MSNA) is well established, with greater activity occurring during expiration and less during inspiration. Whether ventilation per se affects the longer-term (i.e., minute-to-minute) regulation of MSNA has not been determined. We sought

Objective: A number of sympathetic nervous system (SNS) parameters have been used in cardiovascular psycho-physiology. This study aimed to describe the pattern and redundancy of a set of SNS parameters during peripherally induced changes of cardiac sympathetic activation and reflex modulation

We reasoned that if the lung inflation reflex contributes importantly to apnea-induced sympathetic activation such activation would be attenuated in bilateral lung transplant recipients (LTX). We measured muscle sympathetic nerve activity (MSNA; intraneural electrodes), heart rate, mean arterial

, and whether they would show physiological signs of sympathetic activation. A group whose chief complaint was frequent, unpleasant tension over at least the last six weeks for which they desired treatment, was compared with a group who described themselves as calm. Participants were assessed with structured

Physiol 293: H2313–H2319, 2007. First published July 20, 2007; doi:10.1152/ajpheart.01383.2006.—The purpose of this study was to determine if plasma osmolality alters baroreflex control of sympa-thetic activity when controlling for a change in intravascular volume; we hypothesized that baroreflex

Sympathetic activity is reduced by nCPAP in hypertensive obstructive sleep apnoea patients