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Enhancing Biological Detection With Dendrimer-Based

by A L. Jenkins, Kate K. Ong, Ray Yin, A L. Jenkins, Kate K. Ong, Ray Yin
"... Approved for public release; distribution is unlimited. Dendrimers are highly branched, tree-like polymers that possess precise size and shape, as well as surface groups. Among them, polyamidoamine dendrimers are the most widely studied water-soluble/biocompatible dendritic macromolecules. Such dend ..."
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Approved for public release; distribution is unlimited. Dendrimers are highly branched, tree-like polymers that possess precise size and shape, as well as surface groups. Among them, polyamidoamine dendrimers are the most widely studied water-soluble/biocompatible dendritic macromolecules

Molecular Modelling of Dendrimers for Nanoscale Applications

by Tahir Çagin, Tahir Ça ˘gın, Guofeng Wang, Ryan Martin, Nicholas Breen, III, William A. Goddard - Seventh Foresight Conference on Molecular Nanotechnology , 2000
"... . Dendrimers are well defined, highly branched macromolecules that radiate from a central core and are synthesized through a stepwise, repetitive reaction sequence that guarantees complete shells for each generation, leading to polymers that are monodisperse. The synthetic procedures developed fo ..."
Abstract - Cited by 2 (0 self) - Add to MetaCart
for dendrimer preparation permit nearly complete control over the critical molecular design parameters, such as size, shape, surface/interior chemistry, flexibility, and topology. Recent results suggest that dendritic polymers may provide the key to developing a reliable and economical fabrication

Order and frustration in liquid-crystalline dendrimers

by B I Ostrovskii , N Sulyanov , N A Boiko , V P Shibaev , S B Astaf'ev , L G Yanusova , W H De Jeu
"... Abstract. X-ray diffraction has been used to elucidate the structure and phase behavior of several liquidcrystalline dendrimers with a different surface topology of the terminal chains. This includes secondgeneration liquid-crystalline block and statistical dendrimers with mixed aliphatic and mesog ..."
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Abstract. X-ray diffraction has been used to elucidate the structure and phase behavior of several liquidcrystalline dendrimers with a different surface topology of the terminal chains. This includes secondgeneration liquid-crystalline block and statistical dendrimers with mixed aliphatic

Dynamics and thermodynamics of water in PAMAM dendrimers at subnanosecond time scales

by Shiang-tai Lin, Prabal K. Maiti, William A. Goddard - J. Phys. Chem. B 2005
"... Atomistic molecular dynamics simulations are used to study generation 5 polyamidoamine (PAMAM) dendrimers immersed in a bath of water. We interpret the results in terms of three classes of water: buried water well inside of the dendrimer surface, surface water associated with the dendrimer-water int ..."
Abstract - Cited by 6 (0 self) - Add to MetaCart
Atomistic molecular dynamics simulations are used to study generation 5 polyamidoamine (PAMAM) dendrimers immersed in a bath of water. We interpret the results in terms of three classes of water: buried water well inside of the dendrimer surface, surface water associated with the dendrimer

Preparation of Carbosilane Dendrimers with Perfluorosilane Branches

by Eunhee Nam, Chungkyun Kim , 2011
"... Perfluororosilanes1 are highly stable compound, which used in a wide range of applications to heat resistance, impermeable to chemicals, sliding properties, electric charac-teristics and it has been also exhibit special repellency to water.2-7 In addition, the measurement of wetting property and hyd ..."
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and hydrophobic coating by the use of perfluorosilane film on metal oxide surface are widly studied.1 And as a related subject, dendrimers are well defined macromolecule com-posed a focal point, it has unified and applicable nummerous end groups.8 This report presents the preparation of carbo-silane dendrimers

1 Dendrimers in Cancer Treatment and Diagnosis

by Srinivasa-gopalan Sampathkumar, Kevin J. Yarema
"... Dendrimers are nano-sized, radially symmetric molecules with well-defined, ho-mogeneous and monodisperse structure consisting of tree-like arms or branches. Over the past two decades since the term ‘‘dendrimer’ ’ was formally defined, re-search interest in these molecules has gradually evolved from ..."
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of knowledge exists to synthetically control the physicochemical properties of dendrimers and thereby govern their ensuing bio-logical behaviors. These fundamental scientific advances, coupled with practical methods to covalently conjugate a wide range of bioactive molecules to the surface of a dendrimer

Molecular Modeling of Dendrimers for Nanoscale Applications

by Guofeng Wang, Ryan Martin, Nicholas Breen, William A Goddard Iii - Seventh Foresight Conference on Molecular Nanotechnology , 2005
"... Abstract. Dendrimers are well defined, highly branched macromolecules that radiate from a central core and are synthesized through a stepwise, repetitive reaction sequence that guarantees complete shells for each generation, leading to polymers that are monodisperse. The synthetic procedures develop ..."
Abstract - Cited by 1 (0 self) - Add to MetaCart
developed for dendrimer preparation permit nearly complete control over the critical molecular design parameters, such as size, shape, surface/interior chemistry, flexibility, and topology. Recent results suggest that dendritic polymers may provide the key to developing a reliable and economical fabrication

Structure of DNA-Functionalized Dendrimer Nanoparticles

by Mattaparthi Venkata, Satish Kumar, Prabal K Maiti, Mattaparthi Venkata, Satish Kumar, Prabal K Maiti , 2012
"... Atomistic molecular dynamics simulations have been carried out to reveal the characteristic features of ethylenediamine (EDA) cored protonated (corresponding to neutral pH) poly amido amine (PAMAM) dendrimers of generation 3 (G3) and 4 (G4) that are functionalized with single stranded DNAs (ssDNAs) ..."
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DNAs). The four ssDNA strands that are attached via alkythiolate [-S (CH2)6-] linker molecule to the free amine groups on the surface of the PAMAM dendrimers observed to undergo a rapid conformational change during the 25 ns long simulation period. From the RMSD values of ssDNAs, we find relative stability

Hydrodynamic properties of carbohydrate-coated dendrimers

by Georges M. Pavlova, Evgueniya V. Korneevab, Kornelia Jumelc, Stephen E. Hardingc, E. W. Meijerd, H. W. I. Peerlingsd, J. Fraser Stoddarte, Sergey A. Nepogodievf , 1998
"... The hydrodynamic properties of poly(propylene imine) dendrimers, modified with outer-surface b-thiolactosyl residues (‘‘lactodendri-mers’’) of generation number 1–5, have been investigated by velocity sedimentation, translational diffusion, and viscosity measurements in 0.165 % NaCl aqueous solution ..."
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The hydrodynamic properties of poly(propylene imine) dendrimers, modified with outer-surface b-thiolactosyl residues (‘‘lactodendri-mers’’) of generation number 1–5, have been investigated by velocity sedimentation, translational diffusion, and viscosity measurements in 0.165 % NaCl aqueous

INTERNATIONAL JOURNAL OF PHARMACY & LIFE SCIENCES Dendrimers-a novel drug delivery system

by Patel Shiv Narayan , Sethi Pooja , Ansari Khushboo , Tiwari Diwakar , Sharma Ankit , Singhai A K
"... Abstract Dendrimers are the polymeric materials for targeted delivery of drug molecule. These are the highly branched nanoscopic structure for the potential delivery of bioactive. The structure of these materials has a great impact on their physical and chemical properties. As a result of their uni ..."
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of their unique behaviour dendrimers are suitable for a wide range of biomedical and industrial applications. The bioactive agents can be easily encapsulated into the interior of the dendrimers or chemically attached i.e. conjugated or physically adsorbed onto the dendrimer surface, serving the desired properties
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