The in-vitro activities of trospectomycin, cefpodoxime, cefamandok, ccfonicid, and cefuroxime against /Mactamase-negative and-positive invasive clinical isolates of HaemophUus influenzae type b were determined by the agar dilution method. Trospectomycin and cefpodoxime inhibited 90 % of the strains at concentrations of 5 and 0-06 mg/1, respectively, and no differences between the susceptibilities of the /f-lactamase-negative and-positive strains were noted. The activity of cefpodoxime was minimally affected by increased inoculum size, but significant inoculum effects were noted with cefamandole, cefonicid, and cefuroxime with /i-lactamase positive strains.

The comparative inhibitory and bactericidal activities of meropenem and imipenem against Acinetobacter spp. and Enterobacteriaceae resistant to second generation cephalosporins

The benefit of antibiotic prophylaxis during routine hip arthroplasty is well established with most prophylaxis regimens based on the systemic administration of a second-generation cephalosporin.1, 2 Currently within the UK either

of the antimicrobial agent second-generation cephalosporins in particular have several advantages over other antibiotic choices. They provide broad-spectrum coverage target-ing both gram-positive and gram-negative organisms, good safety profile with minimal side effects, and can be tolerated by penicillin allergic

dose of any one of several cephalosporins has been used effectively. There are no apparent benefits in using a longer course for prophylaxis, nor for choosing a third-generation cephalosporin rather than a first- or second-generation cephalosporin. Several cephalosporins have been employed successfully

with a macrolide, an oral second-generation cephalosporin, or a respiratory fluoroquinolone (ie, gatifloxacin, levoflox-acin, moxifloxacin, or ciprofloxacin) 30 days prior to presen-tation. For each case patient, 5 controls were identified and matched according to age, sex, the presence or absence

for “bronchitis. ” Rapid streptococcal antigen and mononucleosis antibody tests were negative at that time. Three days later, the antibiotic regimen was changed to a second-generation cephalosporin for a pre-sumed urinary tract infection after red blood cells ap-peared in the urine. Urine nitrite and leukocyte

Abstract A rapid and sensitive chemiluminescence (CL) method using flow-injection (FI) has been developed for the determination of a second generation cephalosporin, cefprozil. The method is based on the CL reaction of cefprozil with acidic potassium permanganate and tris (2,2 -bipyridyl

. In contrast, the resistance to ampicillin, extended-spectrum penicillins, and first- and second-generation cephalosporins is significant. Kluyvera is a potentially virulent pathogen that deserves aggressive treatment designed with an awareness of the organism’s antimicrobial resistance patterns. Kluyvera

. Primary liver abscess caused by second-generation cephalosporin-resistant K. pneumoniae strains may be an emerging problem in Taiwan. P rimary liver abscess caused by a single pathogen, Klebsiella pneumoniae, has long been an important infectious complication in diabetic patients in Taiwan (1,2). All K