compute the complex function postulated to underlie pretend play. This model also reveals pretense as an early manifestation of the ability to understand mental states. Aspects of later preschool development, both normal and abnormal, are discussed in the light of the new model. This

In the last few years a new cosmological scenario with a significant smooth Dark Energy (DE) component has emerged. The Cosmic Concordance Model (CCM, from now on) is a spatially flat universe with baryons (Ωb ∼ 4%), cold

-operated channel (SOC) had been identified molecularly. Through the serendipity of Drosophila genetics, a candidate SOC, referred to as Transient Receptor Potential (TRP), has been identified that is essential for the light-induced cation conductance in photoreceptor cells. A combination of in vitro and in vivo

DOI: will be assigned “Dark Photons”, light new vector particles Vµ kinetically mixed with the photon, are a frequently considered extension of the Standard Model. For masses below 10 keV they are emitted from the solar interior. In the limit of small mass mV the dark pho-ton flux is strongly

Economics is solidly based on the workings of incentives. Extra rewards will increase and extra costs will decrease the frequency of a particular type of behavior. In sociology, Weber had pointed to a kind of behavior that was presumably not steered by incentives: value-rational behavior, found in religions and

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volume 11, issue 1 Pierce now sold as Thermo Scientific Protein A, G, A/G, L, Melon Gel and desalting resin are automation-compatible. Popular Thermo Scientific antibody purification resins and Thermo Scientific Zeba * Desalting Matrix are now available packaged in convenient, reliable, high-capacity cartridges that are compatible with major automated chromatography systems and manual syringe processing. Thermo Scientific Pierce® Cartridges can be used as single units or connected in a series to obtain even higher column capacities. The crosslinked agarose resins withstand the normal operating pressures used in automated systems and can be regenerated for repeated use. CONTINUED ON PAGE 2

Our attention was captured by the interest-ing debate on the identification of lipofuscins, lipofuscin-like lipopigments, or flavins as the responsible for intracellular autofluorescence (AF) detected in epithelial cancer stem cells when exciting at 480-490 nm. Evidence was provided leading to ascribe AF emission to flavins accumulating in cytoplasmic struc-tures, bounded to membranes and bearing ATP-dependent ABCG2 transporters. Flavins were then proposed as an intrinsic AF bio-marker of cancer stem cells, with advanta-geous implications on cell invasiveness and chemoresistance investigations. It is however worth recalling the huge amount of literature on flavins and NAD(P)H as AF biomarkers of cell energetic metabolism and redox state, an aspect that should not be overlooked in the renewed course to extend the potential of flavins as AF biomarkers, entailing also a recent proposal of Flavin-based fluorescent proteins as substitutes of Green fluorescent proteins.