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  Inferring a system of differential equations for a gene regulatory network by using genetic programming (2001) [16 citations — 3 self]

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by Erina Sakamoto
Proc. Congress on Evolutionary Computation
http://www.miv.t.u-tokyo.ac.jp/ibalab/papers/2001/cec2001-es.pdf
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Abstract:

Abstract- This paper describes an evolutionary method for identifying the gene regulatory network from the observed time series data of the gene’s expression. We use a system of ordinary differential equations as a model of the network and infer their right-hand sides by using Genetic Programming (GP). To explore the search space more effectively in the course of evolution, the least mean square (LMS) method is used along with the ordinary GP. We apply our method to three target networks and empirically show how successfully GP infers the systems of differential equations. 1

Citations

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