(Enter summary)
Abstract: We propose a biochemically plausible mechanism for constructing digital
logic signals and gates of significant complexity within living cells.
These mechanisms rely largely on co-opting existing biochemical machinery
and binding proteins found naturally within the cell, replacing difficult protein
engineering problems with more straightforward engineering of novel
combinations of gene control sequences and gene coding regions.
The resulting logic technology, although slow, allows us to... (Update)
Context of citations to this paper: More
...genes coding for output proteins. The most basic element of computation is the inverter, using the design proposed by Knight and Sussman [10]. Each inverter is encoded as a sequence of DNA bases, consisting of an operator (binding site for the input repressor protein) a...
...and activate a remote transcriptional response. In combination with other ongoing work in digitally controlled gene expression [23, 19, 29, 16, 11] this work provides components for a biological substrate for expressing pattern formation. These same components are also a key...
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BibTeX entry: (Update)
Thomas F. Knight Jr. and Gerald Jay Sussman. Cellular gate technology. In Unconventional Models of Computation, pages 257-272, 1997. http://citeseer.ist.psu.edu/jr97cellular.html More
@incollection{ knight98cellular,
author = "Knight and Sussman",
title = "Cellular Gate Technology",
booktitle = "Unconventional Models of Computation, Springer, 1998",
editor = "C. S. Calude and J. Casti and and M. J. Dinneen",
year = "1998",
url = "citeseer.ist.psu.edu/jr97cellular.html" }
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