C. Reidys, C. V. Forst, and P. Schuster. Replication and mutation on neutral networks. Submitted, 1998. Home/Search Document Details and Download
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RNA Shape Space Topology - Cupal, Kopp, Stadler (1999) (3 citations) (Correct)
....of the sequence structure map cause an evolving population to di#use on the neutral networks of a particular secondary structure u until a superior phenotype u # is encountered. At this point the population jumps from S(u) to the neutral network to S(u # ) where the di#usion process starts again [13, 24, 14, 28]. The question therefore becomes which phenotypes (secondary structure) are easily accessible from a given neutral networks, and which ones are hard or impossible to get to in a single step. In other words, we have to define a criterion for deciding whether a structure y is accessible from the ....
C. Reidys, C. Forst, and P. Schuster. Replication and mutation on neutral networks. Bull. Math. Biol., 1998. in press, Santa Fe Institute Preprint 98-04-036.
Towards a Rational Methodology for Using Evolutionary Search.. - Sharpe (2000) (Correct)
....solved by multi restart stochastic hillclimbing and therefore would not help in the quest to understand when GAs would outperform stochastic hill climbing. They have also been criticised for not supporting neutrality (Barnett, 1998) an interesting feature of real world search spaces (Forst Reidys, 1995; Huynen, Stadler, W. 1996; Hoshino Tsuchida, 1996) However, even knowing these limitations the NK model Chapter 1. Introduction 5 of fitness landscapes can still be a useful tool for initial investigations (Hordijk Manderick, 1995; Mayley, 1996; Eiben Schippers, 1996; Heckendorn ....
....global optimum, with fitness 2n is at the origin: 0, 0, 0] A possible depiction of a 10 dimensional version of this fitness landscape is in figure 3.12. 3.4. 2 Neutral Networks Neutral networks are a feature of search spaces whose importance has only been recognised more recently (Forst Reidys, 1995; Reidys, Forst, Schuster, 199; Huynen et al. 1996; Hoshino Tsuchida, 1996) For some kinds of search spaces the fitness landscape will have connected groups of points on the landscape which have identical fitness to each other. This group need not be only in one area they may form a ....
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Reidys, C., Forst, C., & Schuster, P. (199?). Replication and mutation on neutral networks. In Submitted to Bulletin of Mathematical Biology. Reinitz, J., & Sharp, D. (1995). Mechanism of eve stripe formation. Mechanisms of Development, 49, 133--158.
Evolution At Molecular Resolution - Schuster Institute For Self-citation (Schuster) (Correct)
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C. Reidys, C. V. Forst, and P. Schuster. Replication and mutation on neutral networks. Submitted, 1998.
Molecular Insights into Evolution of Phenotypes - Schuster (2000) (3 citations) Self-citation (Schuster) (Correct)
.... good [23] For the sake of completeness we mention that the computation of an error threshold of replication and mutation has been extended to the diploid case [108] as well as to neutral evolution where stationarity refers to time independent distributions of phenotypes rather than genotypes [80]. Quasispecies formation has been studied also on a dynamical landscape [72] Although all entries of the mutation matrix are now computable from a few input parameters, still more empirical data are required. As in the selection equation (1) the fitness values of phenotypes enter the kinetic ....
Reidys, C., C. Forst, and P. Schuster, "Replication and Mutation on Neutral Networks". J. Math. Biol. (2000), in press.
Molecular Insights into Evolution of Phenotypes - Schuster (2000) (3 citations) Self-citation (Schuster) (Correct)
.... good [22] For the sake of completeness we mention that the computation of an error threshold of replication and mutation has been extended to the diploid case [97] as well as to neutral evolution where stationarity refers to time independent distributions of phenotypes rather than genotypes [72]. 14 Evolution of Phenotypes Although all entries of the mutation matrix are now computable from a few input parameters, still more empirical data are required. As in the selection equation (1) the fitness values of phenotypes enter the kinetic differential equations (3) as parameters. ....
Reidys, C., C. Forst, and P. Schuster, "Replication and Mutation on Neutral Networks". J. Math. Biol. (2000), in press.
Evolution At Molecular Resolution - Schuster Self-citation (Schuster) (Correct)
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C. Reidys, C. V. Forst, and P. Schuster. Replication and mutation on neutral networks. Submitted, 1998.
Topology In Phenotype Space - Cupal, Schuster, Stadler Self-citation (Schuster) (Correct)
....of the sequence structure map cause an evolving population to di#use on the neutral networks of a particular secondary structure x until a superior phenotype x # is encountered. At this point the population jumps from S(x) to the neutral network to S(x # ) where the di#usion process resumes [6, 13, 16]. The evolutionary trajectories observed in computer simulations can be regarded as a sequence (x 0 , x 1 , of those phenotypes on whose neutral networks the population is concentrated during subsequent di#usion phases. The question hence becomes whether there is a meaningful way of ....
C. Reidys, C. Forst, and P. Schuster. Replication and mutation on neutral networks. Bull. Math. Biol., 1999. in press, Santa Fe Institute Preprint 98-04-036. J. Cupal, P. Schuster, P.F. Stadler
Plasticity, Evolvability, and Modularity in RNA - Ancel, Fontana (2000) (1 citation) (Correct)
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Reidys C, Forst CV, Schuster P. 1998. Replication and mutation on neutral networks. Preprint SFI 98-04-036. Available electronically from www.santafe.edu. Santa Fe: Santa Fe Institute.
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