| Claus EB, Risch N, Thompson WD. Autosomal dominant inheritance of early-onset breast cancer. Cancer 1994;73(3):643--50. |
....relatives with breast and ovarian cancer status and age(s) at diagnosis, if applicable, and current age, or age at death indicated for each member. The model assumes that inheritance of BRCA1 and BRCA2 genes is autosomal dominant and independent, assumptions supported in the literature (Claus et al. 1994). More than 100 mutations have been discovered but we make a distinction only between mutations prevalent in the Ashkenazi Jewish population as opposed to all others. Within each subpopulation we consider only two types of alleles: normal and mutated. An individual s BRCA1 and BRCA2 genotype ....
Claus, E. B., Risch, N., and Thompson, W. D. (1994). Autosomal dominant inheritance of early-onset breast cancer: Implications for risk prediction. Cancer, 73:643--651.
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Claus EB, Risch N, Thompson WD. Autosomal dominant inheritance of early-onset breast cancer. Cancer 1994;73(3):643--50.
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