| R.J. Valentino, R. Dingledine, Presynaptic inhibitory effect of acetylcholine in the hippocampus, J. Neurosci. 1 (1981) 784 -- 792. |
....to strongly suppress excitatory synaptic transmission at specific connections within the hippocampal formation. For example, acetylcholine and cholinergic agonists suppress synaptic potentials elicited in the middle molecular layer of the dentate gyrus [51,52] in stratum radiatum of region CA3 [53,54] and in stratum radiatum of region CA1 [53,55 57] These effects appear to be selective to specific synapses, since cholinergic agonists have much weaker effects on synaptic transmission in stratum lacunosum moleculare of CA1 [57] and in the outer molecular layer of the dentate gyrus Fig. 2. ....
....at specific connections within the hippocampal formation. For example, acetylcholine and cholinergic agonists suppress synaptic potentials elicited in the middle molecular layer of the dentate gyrus [51,52] in stratum radiatum of region CA3 [53,54] and in stratum radiatum of region CA1 [53,55 57]. These effects appear to be selective to specific synapses, since cholinergic agonists have much weaker effects on synaptic transmission in stratum lacunosum moleculare of CA1 [57] and in the outer molecular layer of the dentate gyrus Fig. 2. Scopolamine blocks effects of acetylcholine within ....
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R.J. Valentino, R. Dingledine, Presynaptic inhibitory effect of acetylcholine in the hippocampus, J. Neurosci. 1 (1981) 784 -- 792.
.... In hippocampal interneurons, ACh causes a rapid excitation of the cell via modulation of a K conductance [60] Several studies have examined the synaptic effects of cholinergic neuromodulation as well (see [29] for review) ACh causes presynaptic suppression of excitatory synaptic transmission [43,77] with a stronger effect in the stratum radiatum than in the stratum lacunosum moleculare [33] It also yields decreased mIPSCs most likely due to the high density of m2 receptors on terminals of those interneurons innervating the somata of pyramidal cells [25] Taken together, these findings ....
Valentino RJ, Dingeldine R. Presynaptic inhibitory effect of acetylcholine in the hippocampus. J Neurosci 1981;1:784 -- 92.
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Valentino, R.J. and Dingledine, R. (1981) Presynaptic inhibitory effect of acetylcholine in the hippocampus J. Neurosci. 1, 784--792
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