Cate,J.H., Gooding,A.R., Podell,E., Zhou,K., Golden,B.L., Kundrot,C.E., Cech,T.R. and Doudna,J.A. (1996) Crystal structure of a group I ribozyme domain: principles of RNA packing. Science, 273, 1678--1685.  Home/Search   Document Not in Database   Summary   Related Articles   Check

....the grooves [20] and c. participate in stacking interactions as in the loop B of the hairpin ribozyme [12] d. Base triples extend grooves for protein interaction in BIV TAR RNA [146] and e. mediate the tertiary contact between tetraloops and helical loop receptors, as in the group I ribozymes [15]. f. The loop of an RNA pseudoknot [131] is stabilized by a base quadruple. g. Platforms arise through the interaction of consecutive bases within one strand, rst discovered in adenosine platforms in group I ribozymes [16] h. another adenosine platform in the L11 binding domain of 23 S rRNA ....

....the R26 R44 base pair anking the anticodon stem of some tRNAs) 2. Base triples and quadruples Both Watson Crick and non canonical pairs take part in such motifs. Interaction of a nucleotide in a loop with a base pair in a helix gives rise to a base triplet [17] In group I ribozymes ( gure 5e, [15, 133], a base triple is responsible for the tertiary contact between a tetraloop and its receptor. The same motif also serves as an example of a G A C:G quadruple where an additional guanosine is associated by hydrogen bonding. 3. Platforms Consecutive base pairing within one strand accounts for the ....

J. H. Cate, A. R. Gooding, E. Podell, K. Zhou, B . L. Golden, A. A. Szewczak, C. D. Kundrot, T. R. Cech, and J. A. Doudna. Crystal structure of a group I ribozyme domain: Principles of RNA packing. Science, 273:1678-1685, 1996.

.... limited (Uhlenbeck et al. 1997) Crystallization and X ray crystallography have been successful only for tRNAs, small oligonucleotides (e.g. Perbandt et al. 1998) as well as recently for the hammerhead ribozyme (Pley et al. 1994; Scott et al. 1995) the catalytic domain of a group I intron (Cate et al. 1996), and a hepatitis delta virus ribozyme (Ferr D Amar et al. 1998) In the last few years substantial progress was made by combining NMR spectroscopic methods and distance constraint calculations or restrained molecular dynamics in the determination of the structure of small RNA fragments. The ....

Cate, J. H., Gooding, A. R., Podell, E., Zhou, K., Golden, B. L., Kundrot, C. E., Cech, T. R. & Doudna, J. A. (1996). Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing. Science 273, 1696-1699.

....of ribozyme catalysis is caused by the secondary structure in the cofolded complex between substrate and catalyst. called hammerhead (figure 3) because of its characteristic secondary structure shape [96] Three dimensional structures are now available for three classes of RNA cleaving ribozymes [73, 87, 8, 29] and these data revealed the mechanism of RNA catalyzed cleavage reactions in full molecular detail. Additional catalytic RNA molecules were obtained through selection from random or partially random RNA libraries and subsequent evolutionary optimization (see section 6) RNA catalysis in ....

J. H. Cate, A. R. Gooding, E. Podell, K.Zhou, B. L. Golden, C. E. Kundrot, T. R. Cech, and J. A. Doudna. Crystal structure of a group I ribozyme domain: Principles of RNA packing. Science, 273:1678--1685, 1996.

....of ribozyme catalysis is caused by the secondary structure in the cofolded complex between substrate and catalyst. called hammerhead ( gure 3) because of its characteristic secondary structure shape [96] Three dimensional structures are now available for three classes of RNA cleaving ribozymes [73, 87, 8, 29] and these data revealed the mechanism of RNA catalyzed cleavage reactions in full molecular detail. Additional catalytic RNA molecules were obtained through selection from random or partially random RNA libraries and subsequent evolutionary optimization (see section 6) RNA catalysis in ....

J. H. Cate, A. R. Gooding, E. Podell, K.Zhou, B. L. Golden, C. E. Kundrot, T. R. Cech, and J. A. Doudna. Crystal structure of a group I ribozyme domain: Principles of RNA packing. Science, 273:1678-1685, 1996.

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Cate,J.H., Gooding,A.R., Podell,E., Zhou,K., Golden,B.L., Kundrot,C.E., Cech,T.R. and Doudna,J.A. (1996) Crystal structure of a group I ribozyme domain: principles of RNA packing. Science, 273, 1678--1685.

No context found.

Cate, J.H. et al. (1996) Crystal structure of a group I ribozyme domain: principles of RNA packing, Science 273, 1678-1685 Laura F. Landweber 17

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