J. David Sweatt and Eric R. Kandel. Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation of aplysia sensory neurons. Nature, 339, 1989. Home/Search Document Not in Database Summary Related Articles Check |
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The Role of Chemical Mechanisms in Neural Computation and Learning - Hiller (Correct)
....time delaybetween successive presentations affect the degree to which the animal s long term response changes. These phenomena are defined in Section 3.1.1. Mechanisms for long term learning have not yet been extensively explored, though it appears to involve both the production of new proteins [12, 65] and new synapse formation [17] One apparent mechanism for DNA transcription in long term sensitization is cAMP dependent phosphorylation of a substrate protein that acts as a DNA transcription factor [12] This protein, when activated by cAMP, binds to a particular DNA sequence and activates ....
.... What, then, is the function of the proteins encoded by these up or down regulated genes One answer is that they may lead to long term changes in phosphorylation of the same set of substrate proteins that is phosphorylated in a short term manner by the presence of cAMP in the presynaptic terminal [65]. In this case, long term facilitation would be mediated by long term spike broadening, via the long term inactivation of K channels. One set of proteins which are down regulated during long term sensitization has been identified as an NCAM related class of cell adhesion molecules, which ....
J. David Sweatt and Eric R. Kandel. Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation of aplysia sensory neurons. Nature, 339, 1989.
The Role of Chemical Mechanisms in Neural Computation and Learning - Martha Jean (Correct)
....the degree to which the animal s long term response changes. 8 These phenomena are defined in Section 3.1.1. 34 CHAPTER 3. SYNAPTIC PLASTICITY IN APLYSIA Mechanisms for long term learning have not yet been extensively explored, though it appears to involve both the production of new proteins [12, 65] 9 and new synapse formation [17] One apparent mechanism for DNA transcription in long term sensitization is cAMP dependent phosphorylation of a substrate protein that acts as a DNA transcription factor [12] This protein, when activated by cAMP, binds to a particular DNA sequence and activates ....
.... What, then, is the function of the proteins encoded by these up or down regulated genes One answer is that they may lead to long term changes in phosphorylation of the same set of substrate proteins that is phosphorylated in a short term manner by the presence of cAMP in the presynaptic terminal [65]. In this case, long term facilitation would be mediated by long term spike broadening, via the long term inactivation of K channels. One set of proteins which are down regulated during long term sensitization has been identified as an NCAM related class of cell adhesion molecules, which ....
J. David Sweatt and Eric R. Kandel. Persistent and transcriptionally-dependent increase in protein phosphorylation in long-term facilitation of aplysia sensory neurons. Nature, 339, 1989.
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