| E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D Phantom To Simulate Cerebral Blood Flow and Metabolic Images for PET", IEEE Trans. Nuclear Sci, 37, pp. 616--620, 1990. |
....of biodistribution and anatomical shape variation. Cargill [1] addressed aspects of all three considerations in a digital SPECT phantom for imaging cirrhotic liver. For brain phantoms used for SPECT blood flow and PET metabolism studies, one approach has been to use 3D segmented MR brain scans [2, 3] or 2D segmentations of stained human brain tissue [4] Here, radionuclide activity assignment is accomplished typically by setting constant activities in all gray, white, and cerebro spinal fluid (csf) regions, respectively. Interestingly, values for these ratios (typ. 8:2:1 ratios in gray, ....
E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D Phantom To Simulate Cerebral Blood Flow and Metabolic Images for PET", IEEE Trans. Nuclear Sci, 37, pp. 616--620, 1990.
....Ideally, an exemplar should be a record of the radionuclide spatial density in a human patient. Since there is no way to record ground truth functional patterns in humans, one often resorts to physical or software phantoms. These are typically idealized versions of the expected functional pattern [4]. An opportunity to record ground truth functional patterns, does exist, however, for animal models in the form of autoradiography. Successful reconstruction of ground truth biological data is appealing, but the validity of the extension to humans from animal models, even advanced primates, ....
E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D Phantom To Simulate Cerebral Blood Flow and Metabolic Images for PET", IEEE Trans. Nuclear Sci, 37, pp. 616--620, 1990.
.... tomography (SPECT) and positron emission tomography (PET) that various pharmaceuticals tend to concentrate somewhat uniformly in grey matter and in white matter and are absent from cerebro spinal fluid (CSF) with a ratio of concentration approximately 4:1:0 for grey, white, and CSF, respectively [9, 10, 11]. Our own early work incorporated one such prior, a weak membrane model, to capture notions of piecewise smoothness [12, 8, 13, 14] Most of the simulation experiments were done with the mathematical phantoms which were 2 themselves piecewise constant. Reconstruction algorithms, including our ....
E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D Phantom To Simulate Cerebral Blood Flow and Metabolic Images for PET", IEEE Trans. Nuclear Sci, 37, pp. 616--620, 1990.
....of biodistribution and anatomical shape variation. Cargill [1] addressed aspects of all three considerations in a digital SPECT phantom for imaging cirrhotic liver. For brain phantoms used for SPECT blood flow and PET metabolism studies, one approach has been to use 3D segmented MR brain scans [2, 3] or 2D segmentations of stained human brain tissue [4] Here, radionuclide activity assignment is accomplished typically by setting constant activities in all gray, white, and cerebro spinal fluid (csf) regions, respectively. Interestingly, values for these ratios (typ. 8:2:1 ratios in gray, ....
E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D Phantom To Simulate Cerebral Blood Flow and Metabolic Images for PET", IEEE Trans. Nuclear Sci, 37, pp. 616--620, 1990.
....hyperparameters fi j , j = 1; 2; N . V. SIMULATION RESULTS A. Validation of Approximations of CRC and Variance: Quadratic Priors To test the accuracy of the approximate CRC and variance expressions we simulated data for the CTI EXACT HR scanner using a 2D slice of the Hoffman phantom [36] (Fig. 4) with activity ratios in grey matter, white matter and CSF of 5:1:0. The attenuation factors were computed by assigning a constant attenuation coefficient of 0.095 cm to the support of the phantom. A preconditioned conjugate gradient method [12] was used in computing MAP reconstructions. ....
E. Hoffman, P. Cutler, W. Digby, and J. Mazziotta, "3D phantom to simulate cerebral blood flow and metabolic images for PET," IEEE Transactions on Nuclear Science, vol. 37, pp. 616--620, 1990.
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E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D Phantom To Simulate Cerebral Blood Flow and Metabolic Images for PET", IEEE Trans. Nuclear Sci, 37, pp. 616--620, 1990.
No context found.
E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D phantom to simulate cerebral blood flow and metabolic images for PET," IEEE Trans. Nucl. Sci., vol. 37, no. 2, pp. 616--620, 1990.
No context found.
E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D Phantom To Simulate Cerebral Blood Flow and Metabolic Images for PET", IEEE Trans. Nuclear Sci, 37, pp. 616--620, 1990.
No context found.
E. Hoffman, P. Cutler, W. Digby, and J. Mazziotta, "3D phantom to simulate cerebral blood flow and metabolic images for PET," IEEE Transactions on Nuclear Science, vol. 37, pp. 616--620, 1990.
No context found.
E. J. Hoffman, P. D. Cutler, W. M. Digby, and J. C. Mazziotta, "3-D phantom to simulate cerebral blood flow and metabolic images for PET," IEEE Trans. Nucl. Sci. 37, pp 616-620, 1990.
No context found.
Hoffman E.J., Cutler P.D., Digby W.M., and Mazziotta J.C. (1990), "3-D phantom to simulate cerebral blood flow and metabolic images for PET," IEEE Transaction on Nuclear Science , NS-37, 616--620.
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