Kholodenko, B.N., Kiyatkin, A., Bruggeman, F., Sontag E.D., Westerho#, H. and Hoek, J.: `Untangling the wires: a novel strategy to trace functional interactions in signaling and gene networks', Proceedings of the National Academy of Sciences USA, 2002, 99, pp. 12841-12846. Home/Search Document Not in Database Summary Related Articles Check |
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Kholodenko, B.N., Kiyatkin, A., Bruggeman, F., Sontag E.D., Westerho#, H. and Hoek, J.: `Untangling the wires: a novel strategy to trace functional interactions in signaling and gene networks', Proceedings of the National Academy of Sciences USA, 2002, 99, pp. 12841-12846.
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B. N. Kholodenko, A. Kiyatkin, F. Bruggeman, E.D. Sontag, H. Westerho#, and J. Hoek, Untangling the wires: a novel strategy to trace functional interactions in signaling and gene networks, Proceedings of the National Academy of Sciences USA 99, pp. 12841-12846, 2002.
Determination of Functional Network Structure from Local.. - Kholodenko, Sontag Self-citation (Kholodenko Sontag) (Correct)
.... to determine the interaction graph of a system (1) that is to say, to know which variables directly influence which variables, as well as the relative strengths of these interactions ( 3] A more limited goal might be to determine if a certain feedback loop is present in the system (cf. [4]) To help in this task, experimental data is usually available, measuring solutions of system (1) for various initial states and parameter settings. A special case, the one treated in this note, is that in which experimental data provides us with the location of steady states associated to ....
....## i #p j s, and a potentially much smaller number of parameter perturbations may be required. 4 Modular Approach It is also possible to apply our techniques in a modular context, in which only the derivatives #f i #x j with respect to communicating intermediaries are calculated ([4]) Let us briefly explain this. We assume that the entire network consists of an interconnection of n subsystems or modules , each of which is described by a set of di#erential equations such as: x j = g j (y j , x 1 , x n , p 1 , pm ) y j = G j (y j , x 1 , x n , p 1 ....
Kholodenko, B.N., Kiyatkin A., Bruggeman F., Sontag E.D., Westerho# H., Hoek J. (2002) "Untangling the wires: a novel strategy to trace functional interactions in signaling and gene networks," submitted for publication. 6
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