| A. Thayer. Genomics moves on, Oct 14 2002. Chemical and Engineering News. |
....is virtual screening, the testing of hundreds of thousands (to millions) of candidate drug molecules to see if they alter the activity of a target protein that results in unhealthy a#ects. At present, all commercial drugs address only 122 targets, with the top 100 selling drugs addressing only 45[29]. Current estimates place the number of druggable genes at 5 10,000, with each gene encoding for around ten proteins, with two to three percent considered high value targets. Testing typically involves assessing the binding a#nity of the test molecule to a specific place on a protein in a ....
A. Thayer, Genomics moves on, Chemical and Engineering News (Oct 14 2002).
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A. Thayer. Genomics moves on, Oct 14 2002. Chemical and Engineering News.
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