Ferrell, Jr., J.E. and Machleder, E.M.: `The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes', Science, 1998, 280, pp. 895--898. Home/Search Document Not in Database Summary Related Articles Check |
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Noise and Information in Neural Codes - Schneidman (Correct)
....noise, is a reoccurring theme in biology and biophysics. It has been discussed as an important component of the design and reliability of biochemical switches [136, 19] synaptic modification [85, 19] genetic regulation networks and replication [133, 60] and individuality of single organisms [166, 49]. It would be interesting to compare the noise characteristics in these systems, as well as common features in terms of overcoming the noise by using a population of noisy elements and even relying on the existence of noise to improve the system performance. Biophysical design principles of ....
J.E. Ferrell and E.M. Machleder. The biochemical basis of an all-or-none cell fate switch in xenopus oocytes. Science, 280:895--898, 1998.
Roles of Positive and Negative Feedback in Biological Systems - Cinquin, Demongeot (2002) (Correct)
....which is energetically costly. It would be quite wasteful for a switch molecule to be under strong, simultaneous synthesis and degradation, as would be the case in the paradigmatic example described above. A way in which this can be avoided is by filtering out small stimuli , as formulated in [31], so that competition between positive and negative feedback circuits is kept at a minimum. This filtering process can be provided by sigmoidal response curves; MAP kinase cascades, often involved in switch like responses, exhibit such a type of response [31] and also have a positive feedback ....
....out small stimuli , as formulated in [31] so that competition between positive and negative feedback circuits is kept at a minimum. This filtering process can be provided by sigmoidal response curves; MAP kinase cascades, often involved in switch like responses, exhibit such a type of response [31], and also have a positive feedback circuit [31, 32] The situation is thus the following: given a system which already exhibits some switch like responses, even if quite imperfect, positive feedback circuits make it possible to give to the system an almost perfect switch like behaviour; the ....
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Ferrell J.E. Jr, Machleder E.M., The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes, Science 280 (1998), 895-898
Some New Directions in Control Theory Inspired by Systems Biology - Sontag (2004) (Correct)
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Ferrell, Jr., J.E. and Machleder, E.M.: `The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes', Science, 1998, 280, pp. 895--898.
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