Eric R. Kandel and James H. Schwartz. Molecular biology of learning: Modulation of transmitter release. Science, 218:433--443, 1982.  Home/Search   Document Not in Database   Summary   Related Articles

....of synaptic depression to habituation. In synaptic depression, neurotransmitter release is reduced by only ten or fifteen percent following prolonged firing. In habituation in Aplysia, bycontrast, synaptic transmission is reduced to thirty percent of its initial value by only a few training trials [30]. The absence of a large effect, however, does not necessarily rule out the functional significance of a candidate cellular mechanism. The lack of positive evidence could be due to limitations in the experiment. For example, localized effects may be lost in the noise if the measuring technique is ....

....of organs including a siphon and gill for breathing. Light tactile stimulation of the siphon induces a protective reflex, in which the siphon and gill are contracted and withdrawn into the parapodium (see Figure 3 3. This reflex has been shown to exhibit several forms of first order conditioning [30, 21]. The reflex habituates after repeated tactile stimulation of the siphon, and sensitization occurs following an electrical shock to the tail [28] Simple associative learning has also been found [1] The tail shock is used as the unconditioned stimulus (US) and the conditioned stimulus (CS) is ....

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Eric R. Kandel and James H. Schwartz. Molecular biology of learning: Modulation of transmitter release. Science, 218:433--443, 1982.

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