Pavlides, C. and Winson, J. (1989) Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes J. Neurosci. 8, 2907--2918  Home/Search   Document Not in Database   Summary   Related Articles   Check

....both to area CA1 and to the output layers of the entorhinal cortex, one of the parahippocampal regions. Thus, patterns stored in the hippocampus might complete themselves during hippocampal sharp waves, thereby providing an opportunity for reinstatement in the neocortex. In support of this idea, Pavlides and Winson (1989) have shown that hippocampal neurons which have been selectively activated during a prior episode of waking behavior are selectively more active during subsequent slow wave and paradoxical sleep. More recently, Wilson and McNaughton (1993) have found that the cross correlation structure that ....

Pavlides, C. & Winson, J. (1989). Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes. Journal of Neuroscience, 9 (8), 2907--2918.

....expect to see replay of routes. This is shown in Figure 8. Given an initial noisy state, a coherent code forms within half a second, and then over the next few seconds, it drifts along a remembered route. Data supporting a replay of recent experience in hippocampus during sleep were first seen by Pavlides and Winson (1989). They showed that cells with recently visited place fields were more active during REM sleep than other cells whose place fields had not been recently visited. Wilson and The Role of the Hippocampus 87 Figure 8: Replay of routes during LIA without sensory input. A coherent code ....

....are combined with random exploration, a localexcitation weight matrix is formed (see section 2. 1) They demonstrate that when presented with random input and allowed to settle to a stable state, cells with recently visited place fields are more active than other cells, corresponding to data from Pavlides and Winson (1989) and Wilson and McNaughton (1994) They did not, however, look at sequences, as we have in section 2.4. Samsonovich and McNaughton (in press) and Zhang (1996) have suggested that path integration can occur by the motion of a hill of activity on a two dimensional neural sheet, and both demonstrate ....

Pavlides, C., & Winson, J. (1989). Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes. Journal of Neuroscience, 9(8), 2907--2918.

....had previously learnt its way around a maze. Work by O Keefe and others had already shown that the hippocampus of the rat contains a spatial map, so it was perhaps no surprise when the septal lesion destroyed the rat s spatial memory. Lesion studies have their problems, so in Winson and Pavlides ( Pavlides89] decided to record directly from place cells (CA1 and CA3 cells) in the hippocampus of rats. They found that those cells which had been used during the day (because the experimenter had put the rat in those positions of space) had increased firing during subsequent sleep periods (both SWS ....

Pavlides, C; Winson, J. (1989) "Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep periods". J Neurosci. 9.8:2907--2918

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Pavlides, C. and Winson, J. (1989) Influences of hippocampal place cell firing in the awake state on the activity of these cells during subsequent sleep episodes J. Neurosci. 8, 2907--2918

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