| Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57--70. |
....control. New applications in (unmanned) flight control, underwater vehicles, and satellite systems are generating renewed interest in robotics, and many control researchers are becoming active in this area. 10 Figure 7: The wiring diagram of the growth signaling circuitry of the mammalian cell [16]. Despite the enormous progress in robotics over the last half century, the field is very much in its infancy. Today s robots still exhibit extremely simple behaviors compared with humans, and their ability to locomote, interpret complex sensory inputs, perform higher level reasoning, and ....
D. Hanahan and R. A. Weinberg. The hallmarks of cancer. Cell, 100:57--70, 2000. 21
....with each other through lego like fitting The Panel would like to thank Eduardo Sontag for his contributions to this section, based on his Reid Prize plenary lecture at the 2001 SIAM Annual Meeting. Figure 3.9. The wiring diagram of the growth signaling circuitry of the mammalian cell [16]. of parts in lock and key fashion, and their conformation also enhances or represses DNA expression through selective binding. One may view cell life as a huge wireless network of interactions among proteins, DNA, and smaller molecules involved in signaling and energy transfer. As a large ....
D. Hanahan and R. A. Weinberg. The hallmarks of cancer. Cell, 100:57--70, 2000.
....of incurring 4 mutations is astronomically small. If these mutations must occur in speci c loci, such as the coding regions of tumor suppressor genes and oncogenes, then the probability of developing cancer would be even smaller. Yet we believe that cancer requires a whole series of mutations [1, 36, 42, 11], and cancer is a frequent event during human lifespans. 2.2 Mutator Phenotype One explanation for this paradox, o ered in Loeb [21] is the idea of a mutator phenotype. Loeb s calculation changes if an early mutation, perhaps in p53, increases the mutation rate in the rest of the cell. Let us ....
D. Hanahan and R. A. Weinberg. The hallmarks of cancer. Cell, 100:57-70, 2000.
....from different precursors (Golub et al. 1999) and B cell lymphoma (Alizadeh et al. 2000) Low error rates (0 10 ) are achieved in these morphological and lineage classifications. However, these works only tackle binary classification problems. As there are over a hundred types of cancer (Hanahan and Weinberg (2000)) and potentially even more subtypes, for any practical applications it is essential to develop multiclass methodologies for molecular classification. By extending to simultaneous classifications of multiple tumor types, the problem becomes intrinsically more difficult. As there is only one ....
Hanahan, D. and R. Weinberg (2000). The hallmark of cancer.
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Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100: 57--70.
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D. Hanahan, R.A. Weinberg, The hallmarks of cancer, Cell 100 (2000) 57 -- 70.
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Hanahan, D. and Weinberg, R.A.: `The hallmarks of cancer', Cell, 2000, 100, pp. 57--70.
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D. Hanahan and R. A. Weinberg. The hallmarks of cancer. Cell, 100:57--70, January 2000.
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D. Hanahan and R. A. Weinberg. The hallmarks of cancer. Cell, 100:57--70, 2000.
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Hannahan, D. and R.A. Weinberg (2000): The hallmarks of cancer. Cell, 100, 57-70.
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