Fehr, C., Galindo, J., Haubrichs, R., & and Perret, R. (1989). New aromatic musk odorants: Design and synthesis. Helvetica Chimica Acta, 72 , 1537-1553.  Home/Search Document Not in Database Summary Related Articles Check |
This paper is cited in the following contexts:
Multiple-Instance Learning of Real-Valued Data - Amar, Dooly, Goldman, Zhang (2001) (2 citations) (Correct)
....strongly believed to be non musk as negative examples no borderline data was included. The exclusion of borderline data is one of several factors which make the musk data sets easier than one would typically expect. Based on the structural requirements for nitro free aromatic musk molecules [Fehr, 1989], the interaction between a musk molecule and the receptor can be approximately categorized to three di erent interactions. Accordingly, we would expect the degree of importance (or relevance) for the relevant variables to be one of three values depending on which kind of interaction occurs. ....
Fehr, C., Galindo, J., Haubrichs, R., & and Perret, R. (1989). New aromatic musk odorants: Design and synthesis. Helvetica Chimica Acta, 72 , 1537-1553.
Solving the Multiple-Instance Problem with.. - Dietterich, Lathrop, .. (1997) (77 citations) (Correct)
....by expert human judges, whereas drug activity is usually measured quantitatively through biochemical assays. This makes the musk problem somewhat more difficult. We surveyed the literature on musk compounds (Theimer Davies, 1967; Ham Jurs, 1985; Narvaez, Lavine Jurs, 1986; Beets, 1987; Fehr, Galindo, Haubrichs Perret, 1989; Bersuker, Dimoglo, Yu. Gorachov, Vlad Pesaro, 1991) and selected two (overlapping) data sets of musk molecules. Because of the subjective nature of the test for musk strength, there is quite a bit of variation from one paper to another. We considered only compounds that appeared in at least 2 ....
....more important for musk activity. We can see that the preponderance of the bounds are testing the shape of the end of the molecule opposite the oxygen atom. This is a region of hydrophobic bulk , and previous chemical studies had also emphasized the importance of this region for musk activity (Fehr, Galindo, Haubrichs Perret, 1989). There is also a notable absence of any APR bounds on the middle left side of the molecule, which suggests that the molecules have some shape freedom in this area. Finally, note that only a few, tight bounds are needed to test the position of the rings along the axis orthogonal to the plane of ....
Fehr, C., Galindo, J., Haubrichs, R., & Perret, R. (1989). New aromatic musk odorants: Design and synthesis. Helvetica Chimica Acta, 72, 1537--53.
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