| Snel, B., Bork, P. and Huynen, M.A. (1999) Nat. Genet. 21, 108--110 |
.... projects on the horizon, whole genome analysis and especially pairwise genome comparison is a great challenge in genomics (Koonin, 1999; Wooley, 1999) Already there have been proposals to compare genomes using gene order (Boore and Brown, 1998) and gene content(FitzGibbon and House, 1999; Snel et al. 1999). Such comparisons are time consuming as they require gene identi cation. These distances, together with G C content; edit distance; and reversal and rearrangement distances (Kececioglu and Sanko , 1995; Hannenhalli and Pevzner, 1995; Nadeau and Sanko , 1998) compare genomes using only partial ....
.... Ferungulates) The distance matrix can be found at our website (see abstract) The simple asymmetric measure K(xjy) leads to a wrong tree using the same data and programs, as expected (data not shown) The gene order (Boore and Brown, 1998) and gene content (Fitz Gibbon and House, 1999; Snel et al. 1999) approaches, while yielding symmetric distances, have the disadvantage of requiring laborious human analysis of the sequences and also are unlikely to provide enough information to distinguish closely related species such as the above data set. Our method is fully automatic and utilizes the ....
Snel, B., Bork, P., and Huynen, M. A. (1999).
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Snel, B., Bork, P. and Huynen, M.A. (1999) Nat. Genet. 21, 108--110
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