Skaggs, W., and McNaughton, B. 1996. Replay of neuronal firing sequence in rat hippocampus during sleep following spatial experience. Science 271:1870--1873.  Home/Search   Document Not in Database   Summary   Related Articles   Check

....hypothesis is a representation of objects in an animal s environment which is formed by storing relative spatial positions of different objects. There is growing evidence that some storage of relative temporal positions or sequences of events are also in the hippocampus (Nadel Moscovitch 1997; Skaggs McNaughton 1996; Eichenbaum 1996) A number of diverse models for spatial learning and navigation exist in the literature. It is genererally accepted that the hippocampus is the prime site linked with learning of a wide range of tasks, most of which hava a distinct spatial component (O Keefe Nadel 1978; Healy ....

Skaggs, W., and McNaughton, B. 1996. Replay of neuronal firing sequence in rat hippocampus during sleep following spatial experience. Science 271:1870--1873.

....any a priori topological relation encoded in the anatomical connections between two place cells. The connections between hippocampal cells could correspond to other associative connections, which could be equivalent to topological relationships within one given environment. Skaggs and McNaughton [135] reported that two cells with overlapping fields simultaneously recorded in an environment tended to fire more synchronously during the following sleep period of the animal, in the same temporal order as during the spatial behavior. One interpretation of these results is that the 21 Eichenbaum et ....

W. E. Skaggs and B. L. McNaughton. Replay of neuronal firing sequences in rat hippocampus during sleep after spatial experience. Science, 271:1870--1873, 1996.

....on properties of the neural substrate can be interpreted. In our example we will restrict ourselves to the further interpretation of DAC4. Recently, the replay of neuronal ring patterns during sleep, in the same temporal order as during exploration, has been described in the rat hippocampus [39], 38] Although these results have been questioned [29] the existence of two separate learning systems in the hippocampal loop and in the neocortex is well established [43] The role of these separate learning systems has been investigated in abstract terms [26] but these investigations are ....

Skaggs WE, McNaughton BL. Replay of Neuronal Firing Sequences in Rat Hippocampus During Sleep Following Spatial Experience. Science. 1996 Mar 29; 271(5257):1870-3.

.... this kind have been observed [11,15] There are many areas of the brain whose function is based on propagation of activity, such as sound location in the nucleus laminaris [3] It is also possible that propagation of neural activity in the hippocampus is important for navigation and memorization [10]. We have shown here that striated structures can support waves having different speeds which is not possible in single layer structures. These waves in striated structures moving at different speeds can create dynamic patterns with brief intervals of coincidence that are believed to play ....

W. E. Skaggs, B. L. McNaughton, Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience, Science, 271(1996)1870-1873.

....routes are replayed because, when primed with noise, the hippocampal formation settles The Role of the Hippocampus 75 to a stable representation of a location, which then drifts along the routes stored in the CA3 recurrent connections. McNaughton, Skaggs, and Wilson (Wilson McNaughton, 1994; Skaggs McNaughton, 1996) have reported data supporting this hypothesis: simultaneous extracellular recordings from hippocampal pyramidal cells have shown that cells tend to fire in the same sequence during slow wave sleep as they did during recent experience in an environment. We discuss this and its implications for the ....

....path traveled. Finally, as the animal moves through the place field, the timing of the spikes fired by that cell precesses with respect to the theta rhythm: cells behind the animal fire early in the cycle, while cells ahead of the animal fire late in the cycle (O Keefe Recce, 1993; Skaggs, 1995; Skaggs McNaughton, 1996; Skaggs, McNaughton, Wilson, Barnes, 1996) Thus the represented position sweeps across the actual position from back to front with each theta cycle. When combined with the biophysical time course of LTP, this phase precession will also favor connections pointing along routes to a goal (Blum ....

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Skaggs, W. E., & McNaughton, B. L. (1996). Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience. Science, 271, 1870--1873.

.... 2 and 13) The independence is no longer exactly true for cells with highly overlapping place fields [cf. Eichenbaum, Wiener, Shapiro Cohen (1989) In fact, the correlations in the firing of these cells could be strengthened rapidly by Hebbian type learning process (Wilson McNaughton, 1994; Skaggs McNaughton, 1996; Blum Abbott, 1996; Mehta, Barnes McNaughton, 1997) In such a situation, the independence assumption is only a simplifying approximation for theoretical convenience. There is additional information in correlated firing that could be exploited to improve the accuracy of reconstruction. 4.4 ....

Skaggs, W. E. & McNaughton, B. L. (1996). Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience. Science, 271, 1870--1873.

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Skaggs, W.E. and McNaughton, B.L. (1996) Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience Science 271, 1870--1873

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