by Tatsuya Akutsu, Satoru Kuhara, Osamu Maruyama, Satoru Miyano
http://giw.ims.u-tokyo.ac.jp/giw98/cdrom/Paper-pdf/paper16.pdf
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Abstract:
A hot research topic in genomics is to analyze the interactions between genes by systematic gene disruptions and gene overexpressions. Based on a boolean network model without time delay, we have been investigating efficient strategies for identifying a genetic network by multiple gene disruptions and overexpressions. This paper first shows the relationship between our boolean network model without time delay and the standard synchronous boolean network model. Then we present a simulator of boolean networks without time delay for multiple gene disruptions and gene overexpressions, which includes a genetic network identifier with a graphic interface that generates instructions for experiments of gene disruptions and overexpressions. 1
Citations
|
7716
|
Computers and Intractability: A Guide to the Theory of NP-Completeness
– Garey, Johnson
- 1979
|
|
529
|
Queries and concept learning
– Angluin
- 1988
|
|
438
|
Origins of Order: Self-Organization and Selection in Evolution
– Kauffman
- 1993
|
|
324
|
The complexity of computing the permanent
– Valiant
- 1979
|
|
295
|
Exploring the metabolic and genetic control of gene expression on a genomic scale, Science
– DeRisi, Iver, et al.
- 1997
|
|
104
|
The complete genome sequence of Escherichia coli K-12
– Blattner, Plunkett, et al.
- 1997
|
|
103
|
R: REVEAL, a general reverse engineering algorithm for inference of genetic network architectures. Pac Symp Biocomput
– Liang, Fuhrman, et al.
|
|
83
|
Identification of genetic networks from a small number of gene expression patterns under the Boolean network model
– Akutsu, Miyano, et al.
- 1999
|
|
66
|
Complexity of identification and dualization of positive Boolean functions
– Bioch, Ibaraki
- 1995
|
|
45
|
Dynamical behaviour of biological regulatory networks: I. Biological rool of feedback loops and practical use of the concept of the loop-characteristicstate
– Thomas, Thieffry, et al.
- 1995
|
|
39
|
The complete genome sequence of the gram-positive bacterium bacillus subtilis Nature
– Kunst
- 1997
|
|
35
|
Identification of gene regulatory networks by strategic gene disruptions and gene overexpressions
– Akutsu, Kuhara, et al.
- 1998
|
|
31
|
Genomic regulation modeled as a network with basins of attraction
– Wuensche
- 1998
|
|
21
|
Overview of the yeast genome
– Mewes, Albermann, et al.
- 1997
|
|
2
|
Functional abstraction from structure in VLSI simulation models
– Lathrop, Hall, et al.
- 1987
|
|
2
|
The GeNet database
– Samsonova, Spirov, et al.
- 1998
|
|
1
|
Modeling the complexityofgenetic networks: Understanding multigene and pleiotropic regulation, Complexity
– Somogyi, Sniegoski
- 1996
|
