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  Assigning Function to CDS Through Qualified Query Answering: Beyond Alignment and Motifs

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by Guo-hua Chen, Terry Gaasterland, Natalia Maltsev, Jorge Lobo
http://www.mcs.anl.gov/home/maltsev/doc/ISMB94.ps
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Abstract:

In this paper, we show how to use qualitative query answering to annotate CDS-to-function relationships with confidence in the score, confidence in the tool, and confidence in the decision about the function. The system, implemented in Prolog, provides users with a powerful tool to analyze large quantities of data that have been produced by multiple sequence analysis programs. Using qualified query answering techniques, users can easily change the criteria for how tools reinforce each other and for how numbers of occurrences of particular functions reinforce each other. They can also alter how different scores for different tools are categorized.

Citations

1184 Basic local alignment search tool – Altschul, Gish - 1990
300 The SWISS-PROT protein sequence data bank and its supplement TrEMBL – Bairoch, Apweiler - 1997
199 Plans as complex mental attitudes – Pollack - 1990
185 Dynamic queries for information exploration: An implementation and evaluation – Ahlberg, Williamson, et al. - 1992
119 Database of homology-derived protein structures and the 38. Fauchere JL, Pliska V. Hydrophobic parameters pi of amino-acid side chains from structural meaning of sequence alignment. Proteins 1991; 9: 56-8 the partitioning of N-acetyl-amino-acid amides. Eu – Sander, Schneider - 1983
89 The PROSITE dictionary of sites and patterns in proteins, its current status – Bairoch - 1993
46 Reasoning on a highlighted user model to respond to misconceptions – McCoy - 1988
40 Modeling the user in natural language systems – Kass, Finin - 1988
40 FLEX: A tolerant and cooperative user interface to databases – Motro - 1990
38 The ENZYME data bank – Bairoch - 1993
26 Protein family classification based on search- Wallace JC, Henikoff S – Henikoff, JG - 1994
24 The significance of protein sequence similarities – Collins, Coulson, et al. - 1988
19 How to recognize interesting topics to provide cooperative answering – Cuppens, Demolombe - 1989
18 Qualified Answers That Reflect User Needs and Preferences – GAASTERLAND, LOBO - 1994
13 Cooperative Answers for Database Queries – Gaasterland - 1992
11 A cooperative answering system – Gaasterland, Godfrey, et al. - 1992
6 From genome sequences to protein function – Bork, Ouzounis, et al. - 1994
3 The genome data base (gdb) -- a human gene mapping repository – Pearson - 1991
2 Embl data library: Nucleotide sequence database: User manual release 36 – EMBL - 1993
2 An automated system for gathering sequence analysis data from multiple tools – Gaasterland, Overbeek - 1994